Linear stability in networks of pulse-coupled neurons

In a first step towards the comprehension of neural activity, one should focus on the stability of the various dynamical states. Even the characterization of idealized regimes, such as a perfectly periodic spiking activity, reveals unexpected difficulties. In this paper we discuss a general approach to linear stability of pulse-coupled neural networks for generic phase-response curves and post-synaptic response functions. In particular, we present: (i) a mean-field approach developed under the hypothesis of an infinite network and small synaptic conductances; (ii) a "microscopic" approach which applies to finite but large networks. As a result, we find that no matter how large is a neural network, its response to most of the perturbations depends on the system size. There exists, however, also a second class of perturbations, whose evolution typically covers an increasingly wide range of time scales. The analysis of perfectly regular, asynchronous, states reveals that their stability depends crucially on the smoothness of both the phase-response curve and the transmitted post-synaptic pulse. The general validity of this scenarion is confirmed by numerical simulations of systems that are not amenable to a perturbative approach.Comment: 13 pages, 7 figures, submitted to Frontiers in Computational Neuroscienc

Synchronization of coupled neural oscillators with heterogeneous delays

We investigate the effects of heterogeneous delays in the coupling of two excitable neural systems. Depending upon the coupling strengths and the time delays in the mutual and self-coupling, the compound system exhibits different types of synchronized oscillations of variable period. We analyze this synchronization based on the interplay of the different time delays and support the numerical results by analytical findings. In addition, we elaborate on bursting-like dynamics with two competing timescales on the basis of the autocorrelation function.Comment: 18 pages, 14 figure

Deterministic Brownian motion generated from differential delay equations

This paper addresses the question of how Brownian-like motion can arise from the solution of a deterministic differential delay equation. To study this we analytically study the bifurcation properties of an apparently simple differential delay equation and then numerically investigate the probabilistic properties of chaotic solutions of the same equation. Our results show that solutions of the deterministic equation with randomly selected initial conditions display a Gaussian-like density for long time, but the densities are supported on an interval of finite measure. Using these chaotic solutions as velocities, we are able to produce Brownian-like motions, which show statistical properties akin to those of a classical Brownian motion over both short and long time scales. Several conjectures are formulated for the probabilistic properties of the solution of the differential delay equation. Numerical studies suggest that these conjectures could be "universal" for similar types of "chaotic" dynamics, but we have been unable to prove this.Comment: 15 pages, 13 figure

Fractional Calculus - Theory and Applications

In recent years, fractional calculus has led to tremendous progress in various areas of science and mathematics. New definitions of fractional derivatives and integrals have been uncovered, extending their classical definitions in various ways. Moreover, rigorous analysis of the functional properties of these new definitions has been an active area of research in mathematical analysis. Systems considering differential equations with fractional-order operators have been investigated thoroughly from analytical and numerical points of view, and potential applications have been proposed for use in sciences and in technology. The purpose of this Special Issue is to serve as a specialized forum for the dissemination of recent progress in the theory of fractional calculus and its potential applications