4 research outputs found

    Time and multiple objectives in scheduling and routing problems

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    Many optimization problems encountered in practice are multi-objective by nature, i.e., different objectives are conflicting and equally important. Many times, it is not desirable to drop some of them or to optimize them in a composite single objective or hierarchical manner. Furthermore, cost parameters change over time which makes optimization problems harder. For instance, in the transport sector, travel costs are a function of travel time which changes depending on the time of the day a vehicle is travelling (e.g., due to road congestion). Road congestion results in tremendous delays which lead to a decrease in the service quality and the responsiveness of logistic service providers. In Chapter 2, we develop a generic approach to deal with Multi-Objective Scheduling Problems (MOSPs) with State-Dependent Cost Parameters. The aim is to determine the set of Pareto solutions that capture the trade offs between the different conflicting objectives. Due to the complexity of MOSPs, an efficient approximation based on dynamic programming is developed. The approximation has a provable worse case performance guarantee. Even though the generated approximate Pareto front consist of fewer solutions, it still represents a good coverage of the true Pareto front. Furthermore, considerable gains in computation times are achieved. In Chapter 3, the developed methodology is validated on the multi-objective timedependent knapsack problem. In the classical knapsack problem, the input consists of a knapsack with a finite capacity and a set of items, each with a certain weight and a cost. A feasible solution to the knapsack problem is a selection of items such that their total weight does not exceed the knapsack capacity. The goal is to maximize the single objective function consisting of the total pro t of the selected items. We extend the classical knapsack problem in two ways. First, we consider time-dependent profits (e.g., in a retail environment profit depends on whether it is Christmas or not)

    A Multiobjective Approach Applied to the Protein Structure Prediction Problem

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    Interest in discovering a methodology for solving the Protein Structure Prediction problem extends into many fields of study including biochemistry, medicine, biology, and numerous engineering and science disciplines. Experimental approaches, such as, x-ray crystallographic studies or solution Nuclear Magnetic Resonance Spectroscopy, to mathematical modeling, such as minimum energy models are used to solve this problem. Recently, Evolutionary Algorithm studies at the Air Force Institute of Technology include the following: Simple Genetic Algorithm (GA), messy GA, fast messy GA, and Linkage Learning GA, as approaches for potential protein energy minimization. Prepackaged software like GENOCOP, GENESIS, and mGA are in use to facilitate experimentation of these techniques. In addition to this software, a parallelized version of the fmGA, the so-called parallel fast messy GA, is found to be good at finding semi-optimal answers in reasonable wall clock time. The aim of this work is to apply a Multiobjective approach to solving this problem using a modified fast messy GA. By dividing the CHARMm energy model into separate objectives, it should be possible to find structural configurations of a protein that yield lower energy values and ultimately more correct conformations
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