Evolvable Smartphone-Based Point-of-Care Systems For In-Vitro Diagnostics

Recent developments in the life-science -omics disciplines, together with advances in micro and nanoscale technologies offer unprecedented opportunities to tackle some of the major healthcare challenges of our time. Lab-on-Chip technologies coupled with smart-devices in particular, constitute key enablers for the decentralization of many in-vitro medical diagnostics applications to the point-of-care, supporting the advent of a preventive and personalized medicine. Although the technical feasibility and the potential of Lab-on-Chip/smart-device systems is repeatedly demonstrated, direct-to-consumer applications remain scarce. This thesis addresses this limitation. System evolvability is a key enabler to the adoption and long-lasting success of next generation point-of-care systems by favoring the integration of new technologies, streamlining the reengineering efforts for system upgrades and limiting the risk of premature system obsolescence. Among possible implementation strategies, platform-based design stands as a particularly suitable entry point. One necessary condition, is for change-absorbing and change-enabling mechanisms to be incorporated in the platform architecture at initial design-time. Important considerations arise as to where in Lab-on-Chip/smart-device platforms can these mechanisms be integrated, and how to implement them. Our investigation revolves around the silicon-nanowire biological field effect transistor, a promising biosensing technology for the detection of biological analytes at ultra low concentrations. We discuss extensively the sensitivity and instrumentation requirements set by the technology before we present the design and implementation of an evolvable smartphone-based platform capable of interfacing lab-on-chips embedding such sensors. We elaborate on the implementation of various architectural patterns throughout the platform and present how these facilitated the evolution of the system towards one accommodating for electrochemical sensing. Model-based development was undertaken throughout the engineering process. A formal SysML system model fed our evolvability assessment process. We introduce, in particular, a model-based methodology enabling the evaluation of modular scalability: the ability of a system to scale the current value of one of its specification by successively reengineering targeted system modules. The research work presented in this thesis provides a roadmap for the development of evolvable point-of-care systems, including those targeting direct-to-consumer applications. It extends from the early identification of anticipated change, to the assessment of the ability of a system to accommodate for these changes. Our research should thus interest industrials eager not only to disrupt, but also to last in a shifting socio-technical paradigm

PERANCANGAN SISTEM INFORMASI PROFIL PELANGGAN

Pentingnya yang mendasari penelitian ini adalah melakukan analisa pemakaian tenaga listrik berdasarkan jenis tarif daya masing-masing yang dibutuhkan oleh pelanggan. Penelitian ini bertujuan untuk membuat perancangan sistem informasi profil pelanggan. Metodologi yang digunakan dalam penelitian ini adalah metode kepustakaan, mencangkup mempelajari buku dan literatur, melakukan penelitian dengan mengadakan pengamatan secara langsung, pengumpulan data, perancangan sistem, menganalisa data, dan menarik kesimpulan. Hasil penelitian ini dapat membantu perusahaan dalam menjalin relasi dengan pelanggan melalui aplikasi customer profil yang dibuat. Kesimpulan penelitian ini bahwa pelanggan memiliki peran utama dalam kesuksesan sebuah perusahaan, dengan bertambahnya pelanggan yang tetap terjaga loyalitasnya, maka pelanggan akan mampu menentukan keberhasilan perusahaan.   Kata Kunci : Tenaga Listrik, Tarif Daya, Sistem Informas, Profil Pelanggan;   Customer Profil. &nbsp

A formal architecture-centric and model driven approach for the engineering of science gateways

From n-Tier client/server applications, to more complex academic Grids, or even the most recent and promising industrial Clouds, the last decade has witnessed significant developments in distributed computing. In spite of this conceptual heterogeneity, Service-Oriented Architecture (SOA) seems to have emerged as the common and underlying abstraction paradigm, even though different standards and technologies are applied across application domains. Suitable access to data and algorithms resident in SOAs via so-called ‘Science Gateways’ has thus become a pressing need in order to realize the benefits of distributed computing infrastructures.In an attempt to inform service-oriented systems design and developments in Grid-based biomedical research infrastructures, the applicant has consolidated work from three complementary experiences in European projects, which have developed and deployed large-scale production quality infrastructures and more recently Science Gateways to support research in breast cancer, pediatric diseases and neurodegenerative pathologies respectively. In analyzing the requirements from these biomedical applications the applicant was able to elaborate on commonly faced issues in Grid development and deployment, while proposing an adapted and extensible engineering framework. Grids implement a number of protocols, applications, standards and attempt to virtualize and harmonize accesses to them. Most Grid implementations therefore are instantiated as superposed software layers, often resulting in a low quality of services and quality of applications, thus making design and development increasingly complex, and rendering classical software engineering approaches unsuitable for Grid developments.The applicant proposes the application of a formal Model-Driven Engineering (MDE) approach to service-oriented developments, making it possible to define Grid-based architectures and Science Gateways that satisfy quality of service requirements, execution platform and distribution criteria at design time. An novel investigation is thus presented on the applicability of the resulting grid MDE (gMDE) to specific examples and conclusions are drawn on the benefits of this approach and its possible application to other areas, in particular that of Distributed Computing Infrastructures (DCI) interoperability, Science Gateways and Cloud architectures developments

Domain architecture a design framework for system development and integration

The ever growing complexity of software systems has revealed many short-comings in existing software engineering practices and has raised interest in architecture-driven software development. A system\u27s architecture provides a model of the system that suppresses implementation detail, allowing the architects to concentrate on the analysis and decisions that are most critical to structuring the system to satisfy its requirements. Recently, interests of researchers and practi-tioners have shifted from individual system architectures to architectures for classes of software systems which provide more general, reusable solutions to the issues of overall system organization, interoperability, and allocation of services to system components. These generic architectures, such as product line architectures and domain architectures, promote reuse and interoperability, and create a basis for cost effective construction of high-quality systems. Our focus in this dissertation is on domain architectures as a means of development and integration of large-scale, domain-specific business software systems. Business imperatives, including flexibility, productivity, quality, and ability to adapt to changes, have fostered demands for flexible, coherent and enterprise--wide integrated business systems. The components of such systems, developed separately or purchased off the shelf, need to cohesively form an overall compu-tational environment for the business. The inevitable complexity of such integrated solutions and the highly-demanding process of their construction, management, and evolution support require new software engineering methodologies and tools. Domain architectures, prescribing the organization of software systems in a business domain, hold a promise to serve as a foundation on which such integrated business systems can be effectively constructed. To meet the above expectations, software architectures must be properly defined, represented, and applied, which requires suitable methodologies as well as process and tool support. Despite research efforts, however, state-of-the-art methods and tools for architecture-based system development do not yet meet the practical needs of system developers. The primary focus of this dissertation is on developing methods and tools to support domain architecture engineering and on leveraging architectures to achieve improved system development and integration in presence of increased complexity. In particular, the thesis explores issues related to the following three aspects of software technology: system complexity and software architectures as tools to alleviate complexity; domain architectures as frameworks for construction of large scale, flexible, enterprise-wide software systems; and architectural models and representation techniques as a basis for good” design. The thesis presents an archi-tectural taxonomy to help categorize and better understand architectural efforts. Furthermore, it clarifies the purpose of domain architectures and characterizes them in detail. To support the definition and application of domain architectures we have developed a method for domain architecture engineering and representation: GARM-ASPECT. GARM, the Generic Architecture Reference Model, underlying the method, is a system of modeling abstractions, relations and recommendations for building representations of reference software architectures. The model\u27s focus on reference and domain architectures determines its main distinguishing features: multiple views of architectural elements, a separate rule system to express constraints on architecture element types, and annotations such as “libraries” of patterns and “logs” of guidelines. ASPECT is an architecture description language based on GARM. It provides a normalized vocabulary for representing the skeleton of an architecture, its structural view, and establishes a framework for capturing archi-tectural constraints. It also allows extensions of the structural view with auxiliary information, such as behavior or quality specifications. In this respect, ASPECT provides facilities for establishing relationships among different specifications and gluing them together within an overall architectural description. This design allows flexibility and adaptability of the methodology to the specifics of a domain or a family of systems. ASPECT supports the representation of reference architectures as well as individual system architectures. The practical applicability of this method has been tested through a case study in an industrial setting. The approach to architecture engineering and representation, presented in this dissertation, is pragmatic and oriented towards software practitioners. GARM-ASPECT, as well as the taxonomy of architectures are of use to architects, system planners and system engineers. Beyond these practical contributions, this thesis also creates a more solid basis for expbring the applicability of architectural abstractions, the practicality of representation approaches, and the changes required to the devel-opment process in order to achieve the benefits from an architecture-driven software technology

Dagstuhl News January - December 2000

"Dagstuhl News" is a publication edited especially for the members of the Foundation "Informatikzentrum Schloss Dagstuhl" to thank them for their support. The News give a summary of the scientific work being done in Dagstuhl. Each Dagstuhl Seminar is presented by a small abstract describing the contents and scientific highlights of the seminar as well as the perspectives or challenges of the research topic

Interim research assessment 2003-2005 - Computer Science

This report primarily serves as a source of information for the 2007 Interim Research Assessment Committee for Computer Science at the three technical universities in the Netherlands. The report also provides information for others interested in our research activities

Systematic construction of goal-oriented COTS taxonomies

El proceso de construir software a partir del ensamblaje e integración de soluciones de software pre-fabricadas, conocidas como componentes COTS (Comercial-Off-The-Shelf) se ha convertido en una necesidad estratégica en una amplia variedad de áreas de aplicación. En general, los componentes COTS son componentes de software que proveen una funcionalidad específica, que están disponibles en el mercado para ser adquiridos e integrados dentro de otros sistemas de software. Los beneficios potenciales de esta tecnología son principalmente la reducción de costes y el acortamiento del tiempo de desarrollo, a la vez que fomenta la calidad. Sin embargo, numerosos retos que van desde problemas técnicos y legales deben ser afrontados para adaptar las actividades tradicionales de ingeniería de software para explotar los beneficios del uso de COTS para el desarrollo de sistemas.Actualmente, existe un incrementalmente enorme mercado de componentes COTS; así, una de las actividades más críticas en el desarrollo de sistemas basados en COTS es la selección de componentes que deben ser integrados en el sistema a desarrollar. La selección está básicamente compuesta de dos procesos principales: La búsqueda de componentes candidatos en el mercado y su posterior evaluación con respecto a los requisitos del sistema. Desafortunadamente, la mayoría de los métodos existentes para seleccionar COTS, se enfocan en el proceso de evaluación, dejando de lado el problema de buscar los componentes en el mercado. La búsqueda de componentes en el mercado no es una tarea trivial, teniendo que afrontar varias características del mercado de COTS, tales como su naturaleza dispersa y siempre creciente, cambio y evolución constante; en este contexto, la obtención de información de calidad acerca de los componentes no es una tarea fácil. Como consecuencia, el proceso de selección de COTS se ve seriamente dañado. Además, las alternativas tradicionales de reuso también carecen de soluciones apropiadas para reusar componentes COTS y el conocimiento adquirido en cada proceso de selección. Esta carencia de propuestas es un problema muy serio que incrementa los riesgos de los proyectos de selección de COTS, además de hacerlos ineficientes y altamente costosos. Esta disertación presenta el método GOThIC (Goal- Oriented Taxonomy and reuse Infrastructure Construction) enfocado a la construcción de infraestructuras de reuso para facilitar la búsqueda y reuso de componentes COTS. El método está basado en el uso de objetivos para construir taxonomías abstractas, bien fundamentadas y estables para lidiar con las características del mercado de COTS. Los nodos de las taxonomías son caracterizados por objetivos, sus relaciones son declaradas como dependencias y varios artefactos son construidos y gestionados para promover la reusabilidad y lidiar con la evolución constante.El método GOThIC ha sido elaborado a través de un proceso iterativo de investigación-acción para identificar los retos reales relacionados con el proceso de búsqueda de COTS. Posteriormente, las soluciones posibles fueron evaluadas e implementadas en varios casos de estudio en el ámbito industrial y académico en diversos dominios. Los resultados más relevantes fueron registrados y articulados en el método GOThIC. La evaluación industrial preliminar del método se ha llevado a cabo en algunas compañías en Noruega.The process of building software systems by assembling and integrating pre-packaged solutions in the form of Commercial-Off-The-Shelf (COTS) software components has become a strategic need in a wide variety of application areas. In general, COTS components are software components that provide a specific functionality, available in the market to be purchased, interfaced and integrated into other software systems. The potential benefits of this technology are mainly its reduced costs and shorter development time, while maintaining the quality. Nevertheless, many challenges ranging form technical to legal issues must be faced for adapting the traditional software engineering activities in order to exploit these benefits.Nowadays there is an increasingly huge marketplace of COTS components; therefore, one of the most critical activities in COTS-based development is the selection of the components to be integrated into the system under development. Selection is basically composed of two main processes, namely: searching of candidates from the marketplace and their evaluation with respect to the system requirements. Unfortunately, most of the different existing methods for COTS selection focus their efforts on evaluation, letting aside the problem of searching components in the marketplace. Searching candidate COTS is not an easy task, having to cope with some challenging marketplace characteristics related to its widespread, evolvable and growing nature; and the lack of available and well-suited information to obtain a quality-assured search. Indeed, traditional reuse approaches also lack of appropriate solutions to reuse COTS components and the knowledge gained in each selection process. This lack of proposals is a serious drawback that makes the whole selection process highly risky, and often expensive and inefficient. This dissertation introduces the GOThIC (Goal- Oriented Taxonomy and reuse Infrastructure Construction) method aimed at building a domain reuse infrastructure for facilitating COTS components searching and reuse. It is based on goal-oriented approaches for building abstract, well-founded and stable taxonomies capable of dealing with the COTS marketplace characteristics. Thus, the nodes of these taxonomies are characterized by means of goals, their relationships declared as dependencies among them and several artifacts are constructed and managed for reusability and evolution purposes. The GOThIC method has been elaborated following an iterative process based on action research premises to identify the actual challenges related to COTS components searching. Then, possible solutions were envisaged and implemented by several industrial and academic case studies in different domains. Successful results were recorded to articulate the synergic GOThIC method solution, followed by its preliminary industrial evaluation in some Norwegian companies

Organisations as complex adaptive systems : implications for the design of information systems

Today a paradigm shift in the field of organisation and management theories is no longer disputed and the need to switch from the Command-and-Control to the Leaming Organisation Paradigm (LOP) in the area of organisational theory is well understood. However, it is less well appreciated that learning organisations cannot operate effectively if supported by centralised databases and tailor-made application programs. LOP emphasises adaptability, flexibility, participation and learning. It is important to understand that the changes in organisational and management strategies will not on their own be able to produce the desired effects unless they are supported by appropriate changes in organisational culture, and by effective information systems. This research demonstrates that conventional information system strategies and development methods are no longer adequate. Information system strategies must respond to these needs of the LOP and incorporate new information systems that are capable of evolving, adapting and responding to the constantly changing business environment. The desired adaptability, flexibility and agility in information systems for LOP can be achieved by exploiting the technologies of the Internet, World Wide Web, intelligent agents and intranets. This research establishes that there is a need for synergy between organisational structures and organisational information systems. To obtain this desired synergy it is essential that new information systems be designed as an integral part of the learning organisational structure itself. Complexity theory provides a new set of metaphors and a host of concepts for the understanding of organisations as complex adaptive systems. This research introduces the principles of Complex Adaptive Systems and draws on their significance for designing the information systems needed to support the new generation of learning organisations. The search for new models of information system strategies for today's dynamic world of business points to the 'swarm models' observed in Nature