Biosensors and CMOS Interface Circuits

abstract: Analysing and measuring of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. Point of care diagnostic system, composing of biosensors, have promising applications for providing cheap, accurate and portable diagnosis. Owing to these expanding medical applications and advances made by semiconductor industry biosensors have seen a tremendous growth in the past few decades. Also emergence of microfluidics and non-invasive biosensing applications are other marker propellers. Analyzing biological signals using transducers is difficult due to the challenges in interfacing an electronic system to the biological environment. Detection limit, detection time, dynamic range, specificity to the analyte, sensitivity and reliability of these devices are some of the challenges in developing and integrating these devices. Significant amount of research in the field of biosensors has been focused on improving the design, fabrication process and their integration with microfluidics to address these challenges. This work presents new techniques, design and systems to improve the interface between the electronic system and the biological environment. This dissertation uses CMOS circuit design to improve the reliability of these devices. Also this work addresses the challenges in designing the electronic system used for processing the output of the transducer, which converts biological signal into electronic signal.Dissertation/ThesisM.S. Electrical Engineering 201

Printed organic TFTs on flexible substrate for complementary circuits

Organic Thin film Transistors (OTFT) have been widely investigated in these last years as potential candidate for the development of low cost, flexible and lightweight active-matrix backplanes for display applications. Indeed the organic semiconductors provide both promising electrical performances tunable by chemistry and the ability to be processed at low temperature with innovative printing technics on various large scale substrates. Thanks to the recent developments on both n-type and p-type solution-processed organic semiconductors, we have developed a printable organic complementary technology compatible with flexible PEN substrates. By combining state of the art materials exhibiting mobility in the range of 1 cm 2 /V.s and silicon inspired compact modeling and simulation approach, we were able to design and fabricate circuit's building blocks that provide the switching, digital and analog functions required for the fabrication of printed systems on foil

High-performance flexible energy storage and harvesting system for wearable electronics.

This paper reports on the design and operation of a flexible power source integrating a lithium ion battery and amorphous silicon solar module, optimized to supply power to a wearable health monitoring device. The battery consists of printed anode and cathode layers based on graphite and lithium cobalt oxide, respectively, on thin flexible current collectors. It displays energy density of 6.98 mWh/cm(2) and demonstrates capacity retention of 90% at 3C discharge rate and ~99% under 100 charge/discharge cycles and 600 cycles of mechanical flexing. A solar module with appropriate voltage and dimensions is used to charge the battery under both full sun and indoor illumination conditions, and the addition of the solar module is shown to extend the battery lifetime between charging cycles while powering a load. Furthermore, we show that by selecting the appropriate load duty cycle, the average load current can be matched to the solar module current and the battery can be maintained at a constant state of charge. Finally, the battery is used to power a pulse oximeter, demonstrating its effectiveness as a power source for wearable medical devices

Low Frequency Electric Field Imaging

abstract: Electric field imaging allows for a low cost, compact, non-invasive, non-ionizing alternative to other methods of imaging. It has many promising industrial applications including security, safely imaging power lines at construction sites, finding sources of electromagnetic interference, geo-prospecting, and medical imaging. The work presented in this dissertation concerns low frequency electric field imaging: the physics, hardware, and various methods of achieving it. Electric fields have historically been notoriously difficult to work with due to how intrinsically noisy the data is in electric field sensors. As a first contribution, an in-depth study demonstrates just how prevalent electric field noise is. In field tests, various cables were placed underneath power lines. Despite being shielded, the 60 Hz power line signal readily penetrated several types of cables. The challenges of high noise levels were largely addressed by connecting the output of an electric field sensor to a lock-in amplifier. Using the more accurate means of collecting electric field data, D-dot sensors were arrayed in a compact grid to resolve electric field images as a second contribution. This imager has successfully captured electric field images of live concealed wires and electromagnetic interference. An active method was developed as a third contribution. In this method, distortions created by objects when placed in a known electric field are read. This expands the domain of what can be imaged because the object does not need to be a time-varying electric field source. Images of dielectrics (e.g. bodies of water) and DC wires were captured using this new method. The final contribution uses a collection of one-dimensional electric field images, i.e. projections, to reconstruct a two-dimensional image. This was achieved using algorithms based in computed tomography such as filtered backprojection. An algebraic approach was also used to enforce sparsity regularization with the L1 norm, further improving the quality of some images.Dissertation/ThesisDoctoral Dissertation Electrical Engineering 201

DATA ON ENGLISH TO JAPANESE TRANSLITERATION OF TECHNICAL TERMINOLOGY

No abstract

Index to 1986 NASA Tech Briefs, volume 11, numbers 1-4

Short announcements of new technology derived from the R&D activities of NASA are presented. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. This index for 1986 Tech Briefs contains abstracts and four indexes: subject, personal author, originating center, and Tech Brief Number. The following areas are covered: electronic components and circuits, electronic systems, physical sciences, materials, life sciences, mechanics, machinery, fabrication technology, and mathematics and information sciences