Testing McClelland at the academy: an analysis of entrepreneurial behavioral characteristics

The aim of this study was to test whether Entrepreneurial Behavioral Characteristics (EBC) develop in Brazilian university students as described by McClelland. Methodological procedures tested McClelland’s (1963;1987) perspective with a sample of university students, also emphasizing the dimensions leading to sustainable businesses. Data collection was performed using a closed questionnaire with fifty-five questions using the Likert scale, applied manually for five years, at the beginning of seven different semesters. The questionnaire was answered by a sample of 238 university students from bachelor’s degrees at a Brazilian public university. Data analysis was based on exploratory factor analysis using the main component method and Varimax rotation and confirmatory factor analysis. It has been pointed out that the 10 dimensions of the EBCs are a single factor which also poses methodological challenges as a tendency of homogenization observed in the respondents, which, in itself, can be challenging for the entrepreneurship strategies expected of universities in the future.This paper is financed by National Funds of the FCT – Portuguese Foundation for Science and Technology within the project «UID/ECO/03182/2019»

Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease

Parasitemia; Parasitic diseases; Bloodstream infectionsParasitemia; Enfermedades parasitarias; Infecciones del torrente sanguíneoParasitèmia; Malalties parasitàries; Infeccions del torrent sanguiniCurrently available drugs against Trypanosoma cruzi infection, which causes 12000 deaths annually, have limitations in their efficacy, safety and tolerability. The evaluation of therapeutic responses to available and new compounds is based on parasite detection in the bloodstream but remains challenging because a substantial proportion of infected individuals have undetectable parasitemia even when using diagnostic tools with the highest accuracy. We characterize parasite dynamics which might impact drug efficacy assessments in chronic Chagas by analyzing pre- and post-treatment quantitative-PCR data obtained from blood samples collected regularly over a year. We show that parasitemia remains at a steady-state independently of the diagnostic sensitivity. This steady-state can be probabilistically quantified and robustly predicted at an individual level. Furthermore, individuals can be assigned to categories with distinct parasitological status, allowing a more detailed evaluation of the efficacy outcomes and adjustment for potential biases. Our analysis improves understanding of parasite dynamics and provides a novel background for optimizing future drug efficacy trials in Chagas disease