47,537 research outputs found
DoctorEye: A clinically driven multifunctional platform, for accurate processing of tumors in medical images
Copyright @ Skounakis et al.This paper presents a novel, open access interactive platform for 3D medical image analysis, simulation and visualization, focusing in oncology images. The platform was developed through constant interaction and feedback from expert clinicians integrating a thorough analysis of their requirements while having an ultimate goal of assisting in accurately delineating tumors. It allows clinicians not only to work with a large number of 3D tomographic datasets but also to efficiently annotate multiple regions of interest in the same session. Manual and semi-automatic segmentation techniques combined with integrated correction tools assist in the quick and refined delineation of tumors while different users can add different components related to oncology such as tumor growth and simulation algorithms for improving therapy planning. The platform has been tested by different users and over large number of heterogeneous tomographic datasets to ensure stability, usability, extensibility and robustness with promising results. AVAILABILITY: THE PLATFORM, A MANUAL AND TUTORIAL VIDEOS ARE AVAILABLE AT: http://biomodeling.ics.forth.gr. It is free to use under the GNU General Public License
Medical Image Segmentation by Water Flow
We present a new image segmentation technique based on the paradigm of water flow and apply it to medical images. The force field analogy is used to implement the major water flow attributes like water pressure, surface tension and adhesion so that the model achieves topological adaptability and geometrical flexibility. A new snake-like force functional combining edge- and region-based forces is introduced to produce capability for both range and accuracy. The method has been assessed qualitatively and quantitatively, and shows decent detection performance as well as ability to handle noise
Image and Volume Segmentation by Water Flow
A general framework for image segmentation is presented in this paper, based on the paradigm of water flow. The major water flow attributes like water pressure, surface tension and capillary force are defined in the context of force field generation and make the model adaptable to topological and geometrical changes. A flow-stopping image functional combining edge- and region-based forces is introduced to produce capability for both range and accuracy. The method is assessed qualitatively and quantitatively on synthetic and natural images. It is shown that the new approach can segment objects with complex shapes or weak-contrasted boundaries, and has good immunity to noise. The operator is also extended to 3-D, and is successfully applied to medical volume segmentation
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Shape-driven segmentation of the arterial wall in intravascular ultrasound images
Segmentation of arterial wall boundaries from intravascular images is an important problem for many applications in the study of plaque characteristics, mechanical properties of the arterial wall, its 3D reconstruction,
and its measurements such as lumen size, lumen radius, and wall radius. We present a shape-driven approach to segmentation of the arterial wall from intravascular ultrasound images in the rectangular domain. In a properly built
shape space using training data, we constrain the lumen and media-adventitia contours to a smooth, closed geometry, which increases the segmentation quality without any tradeoff with a regularizer term. In addition to a shape prior,
we utilize an intensity prior through a non-parametric probability density based image energy, with global image measurements rather than pointwise measurements used in previous methods. Furthermore, a detection step is included to address the challenges introduced to the segmentation process by side branches and calcifications. All these features greatly enhance our segmentation method. The tests of our algorithm on a large dataset demonstrate the effectiveness of our approach
VLT Diffraction Limited Imaging and Spectroscopy in the NIR: Weighing the black hole in Centaurus A with NACO
We present high spatial resolution near-infrared spectra and images of the
nucleus of Centaurus A (NGC 5128) obtained with NAOS-CONICA at the VLT. The
adaptive optics corrected data have a spatial resolution of 0.06" (FWHM) in K-
and 0.11" in H-band, four times higher than previous studies. The observed gas
motions suggest a kinematically hot disk which is orbiting a central object and
is oriented nearly perpendicular to the nuclear jet. We model the central
rotation and velocity dispersion curves of the [FeII] gas orbiting in the
combined potential of the stellar mass and the (dominant) black hole. Our
physically most plausible model, a dynamically hot and geometrically thin gas
disk, yields a black hole mass of M_bh = (6.1 +0.6/-0.8) 10^7 M_sun. As the
physical state of the gas is not well understood, we also consider two limiting
cases: first a cold disk model, which completely neglects the velocity
dispersion; it yields an M_bh estimate that is almost two times lower. The
other extreme case is to model a spherical gas distribution in hydrostatic
equilibrium through Jeans equation. Compared to the hot disk model the best-fit
black hole mass increases by a factor of 1.5. This wide mass range spanned by
the limiting cases shows how important the gas physics is even for high
resolution data. Our overall best-fitting black hole mass is a factor of 2-4
lower than previous measurements. With our revised M_bh estimate, Cen A's
offset from the M_bh-sigma relation is significantly reduced; it falls above
this relation by a factor of ~2, which is close to the intrinsic scatter of
this relation. (Abridged)Comment: 12 pages, 14 figures, including minor changes following the referee
report; accepted for publication in The Astrophysical Journa
Two-Dimensional Spectroscopy of Photospheric Shear Flows in a Small delta Spot
In recent high-resolution observations of complex active regions,
long-lasting and well-defined regions of strong flows were identified in major
flares and associated with bright kernels of visible, near-infrared, and X-ray
radiation. These flows, which occurred in the proximity of the magnetic neutral
line, significantly contributed to the generation of magnetic shear. Signatures
of these shear flows are strongly curved penumbral filaments, which are almost
tangential to sunspot umbrae rather than exhibiting the typical radial
filamentary structure. Solar active region NOAA 10756 was a moderately complex,
beta-delta sunspot group, which provided an opportunity to extend previous
studies of such shear flows to quieter settings. We conclude that shear flows
are a common phenomenon in complex active regions and delta spots. However,
they are not necessarily a prerequisite condition for flaring. Indeed, in the
present observations, the photospheric shear flows along the magnetic neutral
line are not related to any change of the local magnetic shear. We present
high-resolution observations of NOAA 10756 obtained with the 65-cm vacuum
reflector at Big Bear Solar Observatory (BBSO). Time series of
speckle-reconstructed white-light images and two-dimensional spectroscopic data
were combined to study the temporal evolution of the three-dimensional vector
flow field in the beta-delta sunspot group. An hour-long data set of consistent
high quality was obtained, which had a cadence of better than 30 seconds and
sub-arcsecond spatial resolution.Comment: 23 pages, 6 gray-scale figures, 4 color figures, 2 tables, submitted
to Solar Physic
Synchronized Oscillations During Cooperative Feature Linking in a Cortical Model of Visual Perception
A neural network model of synchronized oscillator activity in visual cortex is presented in order to account for recent neurophysiological findings that such synchronization may reflect global properties of the stimulus. In these recent experiments, it was reported that synchronization of oscillatory firing responses to moving bar stimuli occurred not only for nearby neurons, but also occurred between neurons separated by several cortical columns (several mm of cortex) when these neurons shared some receptive field preferences specific to the stimuli. These results were obtained not only for single bar stimuli but also across two disconnected, but colinear, bars moving in the same direction. Our model and computer simulations obtain these synchrony results across both single and double bar stimuli. For the double bar case, synchronous oscillations are induced in the region between the bars, but no oscillations are induced in the regions beyond the stimuli. These results were achieved with cellular units that exhibit limit cycle oscillations for a robust range of input values, but which approach an equilibrium state when undriven. Single and double bar synchronization of these oscillators was achieved by different, but formally related, models of preattentive visual boundary segmentation and attentive visual object recognition, as well as nearest-neighbor and randomly coupled models. In preattentive visual segmentation, synchronous oscillations may reflect the binding of local feature detectors into a globally coherent grouping. In object recognition, synchronous oscillations may occur during an attentive resonant state that triggers new learning. These modelling results support earlier theoretical predictions of synchronous visual cortical oscillations and demonstrate the robustness of the mechanisms capable of generating synchrony.Air Force Office of Scientific Research (90-0175); Army Research Office (DAAL-03-88-K0088); Defense Advanced Research Projects Agency (90-0083); National Aeronautics and Space Administration (NGT-50497
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