2 research outputs found
Adaptive fusion of texture-based grading for Alzheimer's disease classification
[EN] Alzheimer's disease is a neurodegenerative process leading to irreversible mental dysfunctions. To date, diagnosis is established after incurable brain structure alterations. The development of new biomarkers is crucial to perform an early detection of this disease. With the recent improvement of magnetic resonance imaging, numerous methods were proposed to improve computer-aided detection. Among these methods, patch-based grading framework demonstrated state-of-the-art performance. Usually, methods based on this framework use intensity or grey matter maps. However, it has been shown that texture filters improve classification performance in many cases. The aim of this work is to improve performance of patch-based grading framework with the development of a novel texture-based grading method. In this paper, we study the potential of multi-directional texture maps extracted with 3D Gabor filters to improve patch-based grading method. We also proposed a novel patch-based fusion scheme to efficiently combine multiple grading maps. To validate our approach, we study the optimal set of filters and compare the proposed method with different fusion schemes. In addition, we also compare our new texture-based grading biomarker with state-of-the-art methods. Experiments show an improvement of AD detection and prediction accuracy. Moreover, our method obtains competitive performance with 91.3% of accuracy and 94.6% of area under a curve for AD detection. (C) 2018 Elsevier Ltd. All rights reserved.This study has been carried out with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of the Investments for the future Program IdEx Bordeaux (HL-MRI ANR-10-IDEX-03-02), Cluster of excellence CPU and TRAIL (BigDataBrain ANR-10-LABX-57).Hett, K.; Ta, V.; Manjón Herrera, JV.; Coupe, P. (2018). Adaptive fusion of texture-based grading for Alzheimer's disease classification. Computerized Medical Imaging and Graphics. 70:8-16. https://doi.org/10.1016/j.compmedimag.2018.08.002S8167
Towards Practical Application of Deep Learning in Diagnosis of Alzheimer's Disease
Accurate diagnosis of Alzheimer's disease (AD) is both challenging and time
consuming. With a systematic approach for early detection and diagnosis of AD,
steps can be taken towards the treatment and prevention of the disease. This
study explores the practical application of deep learning models for diagnosis
of AD. Due to computational complexity, large training times and limited
availability of labelled dataset, a 3D full brain CNN (convolutional neural
network) is not commonly used, and researchers often prefer 2D CNN variants. In
this study, full brain 3D version of well-known 2D CNNs were designed, trained
and tested for diagnosis of various stages of AD. Deep learning approach shows
good performance in differentiating various stages of AD for more than 1500
full brain volumes. Along with classification, the deep learning model is
capable of extracting features which are key in differentiating the various
categories. The extracted features align with meaningful anatomical landmarks,
that are currently considered important in identification of AD by experts. An
ensemble of all the algorithm was also tested and the performance of the
ensemble algorithm was superior to any individual algorithm, further improving
diagnosis ability. The 3D versions of the trained CNNs and their ensemble have
the potential to be incorporated in software packages that can be used by
physicians/radiologists to assist them in better diagnosis of AD.Comment: 18 pages, 8 figure