SFCN-OPI: Detection and Fine-grained Classification of Nuclei Using Sibling FCN with Objectness Prior Interaction

Cell nuclei detection and fine-grained classification have been fundamental yet challenging problems in histopathology image analysis. Due to the nuclei tiny size, significant inter-/intra-class variances, as well as the inferior image quality, previous automated methods would easily suffer from limited accuracy and robustness. In the meanwhile, existing approaches usually deal with these two tasks independently, which would neglect the close relatedness of them. In this paper, we present a novel method of sibling fully convolutional network with prior objectness interaction (called SFCN-OPI) to tackle the two tasks simultaneously and interactively using a unified end-to-end framework. Specifically, the sibling FCN branches share features in earlier layers while holding respective higher layers for specific tasks. More importantly, the detection branch outputs the objectness prior which dynamically interacts with the fine-grained classification sibling branch during the training and testing processes. With this mechanism, the fine-grained classification successfully focuses on regions with high confidence of nuclei existence and outputs the conditional probability, which in turn benefits the detection through back propagation. Extensive experiments on colon cancer histology images have validated the effectiveness of our proposed SFCN-OPI and our method has outperformed the state-of-the-art methods by a large margin.Comment: Accepted at AAAI 201

Integrated Deep and Shallow Networks for Salient Object Detection

Deep convolutional neural network (CNN) based salient object detection methods have achieved state-of-the-art performance and outperform those unsupervised methods with a wide margin. In this paper, we propose to integrate deep and unsupervised saliency for salient object detection under a unified framework. Specifically, our method takes results of unsupervised saliency (Robust Background Detection, RBD) and normalized color images as inputs, and directly learns an end-to-end mapping between inputs and the corresponding saliency maps. The color images are fed into a Fully Convolutional Neural Networks (FCNN) adapted from semantic segmentation to exploit high-level semantic cues for salient object detection. Then the results from deep FCNN and RBD are concatenated to feed into a shallow network to map the concatenated feature maps to saliency maps. Finally, to obtain a spatially consistent saliency map with sharp object boundaries, we fuse superpixel level saliency map at multi-scale. Extensive experimental results on 8 benchmark datasets demonstrate that the proposed method outperforms the state-of-the-art approaches with a margin.Comment: Accepted by IEEE International Conference on Image Processing (ICIP) 201

Single-Shot Refinement Neural Network for Object Detection

For object detection, the two-stage approach (e.g., Faster R-CNN) has been achieving the highest accuracy, whereas the one-stage approach (e.g., SSD) has the advantage of high efficiency. To inherit the merits of both while overcoming their disadvantages, in this paper, we propose a novel single-shot based detector, called RefineDet, that achieves better accuracy than two-stage methods and maintains comparable efficiency of one-stage methods. RefineDet consists of two inter-connected modules, namely, the anchor refinement module and the object detection module. Specifically, the former aims to (1) filter out negative anchors to reduce search space for the classifier, and (2) coarsely adjust the locations and sizes of anchors to provide better initialization for the subsequent regressor. The latter module takes the refined anchors as the input from the former to further improve the regression and predict multi-class label. Meanwhile, we design a transfer connection block to transfer the features in the anchor refinement module to predict locations, sizes and class labels of objects in the object detection module. The multi-task loss function enables us to train the whole network in an end-to-end way. Extensive experiments on PASCAL VOC 2007, PASCAL VOC 2012, and MS COCO demonstrate that RefineDet achieves state-of-the-art detection accuracy with high efficiency. Code is available at https://github.com/sfzhang15/RefineDetComment: 14 pages, 7 figures, 7 table