Extraction of Transcript Diversity from Scientific Literature

Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems. The numerous examples of the mechanisms and functional implications of these events are scattered throughout the scientific literature. Thus, it is crucial to have a tool that can automatically extract the relevant facts and collect them in a knowledge base that can aid the interpretation of data from high-throughput methods. We have developed and applied a composite text-mining method for extracting information on transcript diversity from the entire MEDLINE database in order to create a database of genes with alternative transcripts. It contains information on tissue specificity, number of isoforms, causative mechanisms, functional implications, and experimental methods used for detection. We have mined this resource to identify 959 instances of tissue-specific splicing. Our results in combination with those from EST-based methods suggest that alternative splicing is the preferred mechanism for generating transcript diversity in the nervous system. We provide new annotations for 1,860 genes with the potential for generating transcript diversity. We assign the MeSH term “alternative splicing” to 1,536 additional abstracts in the MEDLINE database and suggest new MeSH terms for other events. We have successfully extracted information about transcript diversity and semiautomatically generated a database, LSAT, that can provide a quantitative understanding of the mechanisms behind tissue-specific gene expression. LSAT (Literature Support for Alternative Transcripts) is publicly available at http://www.bork.embl.de/LSAT/

Knowledge Management for Biomedical Literature: The Function of Text-Mining Technologies in Life-Science Research

Efficient information retrieval and extraction is a major challenge in life-science research. The Knowledge Management (KM) for biomedical literature aims to establish an environment, utilizing information technologies, to facilitate better acquisition, generation, codification, and transfer of knowledge. Knowledge Discovery in Text (KDT) is one of the goals in KM, so as to find hidden information in the literature by exploring the internal structure of knowledge network created by the textual information. Knowledge discovery could be major help in the discovery of indirect relationships, which might imply new scientific discoveries. Text-mining provides methods and technologies to retrieve and extract information contained in free-text automatically. Moreover, it enables analysis of large collections of unstructured documents for the purposes of extracting interesting and non-trivial patterns of knowledge. Biomedical text-mining is organized in stages classified into the following steps: identification of biological entities, identification of biological relations and classification of entity relations. Here, we discuss the challenges and function of biomedical text-mining in the KM for biomedical literature

Knowledge Management for Biomedical Literature: The Function of Text-Mining Technologies in Life-Science Research

Efficient information retrieval and extraction is a major challenge in life-science research. The Knowledge Management (KM) for biomedical literature aims to establish an environment, utilizing information technologies, to facilitate better acquisition, generation, codification, and transfer of knowledge. Knowledge Discovery in Text (KDT) is one of the goals in KM, so as to find hidden information in the literature by exploring the internal structure of knowledge network created by the textual information. Knowledge discovery could be major help in the discovery of indirect relationships, which might imply new scientific discoveries. Text-mining provides methods and technologies to retrieve and extract information contained in free-text automatically. Moreover, it enables analysis of large collections of unstructured documents for the purposes of extracting interesting and non-trivial patterns of knowledge. Biomedical text-mining is organized in stages classified into the following steps: identification of biological entities, identification of biological relations and classification of entity relations. Here, we discuss the challenges and function of biomedical text-mining in the KM for biomedical literature

KNOWLEDGE DISCOVERY IN ARTIFICIAL NEURAL NETWORKS AND REGRESSION MODELS

In this paper, Artificial Neural Networks (ANN) and Regression Analysis models were considered to determine which ofthem performs better. Prediction was done using one hidden layer and three processing elements in the ANN model.Furthermore, prediction was done using regression analysis. The parameters of regression model were estimated using LeastSquare method. To determine the better prediction, mean square errors (MSE) attached to ANN and regression models wereused. Seven real series were fitted and predicted with in both models. It was found out that the mean square error attached to ANNmodel was smaller than regression model which made ANN a better model in prediction.Keywords: Artificial Neural Networks, Regression, Least Square, Processing Element, Hidden Layer, Mean Square Error.

Biomedical term mapping databases

Longer words and phrases are frequently mapped onto a shorter form such as abbreviations or acronyms for efficiency of communication. These abbreviations are pervasive in all aspects of biology and medicine and as the amount of biomedical literature grows, so does the number of abbreviations and the average number of definitions per abbreviation. Even more confusing, different authors will often abbreviate the same word/phrase differently. This ambiguity impedes our ability to retrieve information, integrate databases and mine textual databases for content. Efforts to standardize nomenclature, especially those doing so retrospectively, need to be aware of different abbreviatory mappings and spelling variations. To address this problem, there have been several efforts to develop computer algorithms to identify the mapping of terms between short and long form within a large body of literature. To date, four such algorithms have been applied to create online databases that comprehensively map biomedical terms and abbreviations within MEDLINE: ARGH (http://lethargy.swmed.edu/ARGH/argh.asp), the Stanford Biomedical Abbreviation Server (http://bionlp.stanford.edu/abbreviation/), AcroMed (http://medstract.med.tufts.edu/acro1.1/index.htm) and SaRAD (http://www.hpl.hp.com/research/idl/projects/abbrev.html). In addition to serving as useful computational tools, these databases serve as valuable references that help biologists keep up with an ever-expanding vocabulary of terms

Electronic data sources for kinetic models of cell signaling

Functional understanding of signaling pathways requires detailed information about the constituent molecules and their interactions. Simulations of signaling pathways therefore build upon a great deal of data from various sources. We first survey electronic data resources for cell signaling modeling and then based on the type of data representation the data sources are broadly classified into five groups. None of the data sources surveyed provide all required data in a ready-to-be-modeled fashion. We then put forward a wish list for the desired attributes for an ideal modeling centric database. Finally, we close with perspectives on how electronic data sources for cell signaling modeling have developed. We suggest that future directions in such data sources are largely model-driven and are hinged on interoperability of data sources