A Formal Approach based on Fuzzy Logic for the Specification of Component-Based Interactive Systems

Formal methods are widely recognized as a powerful engineering method for the specification, simulation, development, and verification of distributed interactive systems. However, most formal methods rely on a two-valued logic, and are therefore limited to the axioms of that logic: a specification is valid or invalid, component behavior is realizable or not, safety properties hold or are violated, systems are available or unavailable. Especially when the problem domain entails uncertainty, impreciseness, and vagueness, the appliance of such methods becomes a challenging task. In order to overcome the limitations resulting from the strict modus operandi of formal methods, the main objective of this work is to relax the boolean notion of formal specifications by using fuzzy logic. The present approach is based on Focus theory, a model-based and strictly formal method for componentbased interactive systems. The contribution of this work is twofold: i) we introduce a specification technique based on fuzzy logic which can be used on top of Focus to develop formal specifications in a qualitative fashion; ii) we partially extend Focus theory to a fuzzy one which allows the specification of fuzzy components and fuzzy interactions. While the former provides a methodology for approximating I/O behaviors under imprecision, the latter enables to capture a more quantitative view of specification properties such as realizability.Comment: In Proceedings FESCA 2015, arXiv:1503.0437

Stone-type representations and dualities for varieties of bisemilattices

In this article we will focus our attention on the variety of distributive bisemilattices and some linguistic expansions thereof: bounded, De Morgan, and involutive bisemilattices. After extending Balbes' representation theorem to bounded, De Morgan, and involutive bisemilattices, we make use of Hartonas-Dunn duality and introduce the categories of 2spaces and 2spaces$^{\star}$. The categories of 2spaces and 2spaces$^{\star}$ will play with respect to the categories of distributive bisemilattices and De Morgan bisemilattices, respectively, a role analogous to the category of Stone spaces with respect to the category of Boolean algebras. Actually, the aim of this work is to show that these categories are, in fact, dually equivalent

Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society

Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud \ud \ud KEYWORDS: Emergence of Life and Human Consciousness;\ud Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud \u

A Topos Foundation for Theories of Physics: I. Formal Languages for Physics

This paper is the first in a series whose goal is to develop a fundamentally new way of constructing theories of physics. The motivation comes from a desire to address certain deep issues that arise when contemplating quantum theories of space and time. Our basic contention is that constructing a theory of physics is equivalent to finding a representation in a topos of a certain formal language that is attached to the system. Classical physics arises when the topos is the category of sets. Other types of theory employ a different topos. In this paper we discuss two different types of language that can be attached to a system, S. The first is a propositional language, PL(S); the second is a higher-order, typed language L(S). Both languages provide deductive systems with an intuitionistic logic. The reason for introducing PL(S) is that, as shown in paper II of the series, it is the easiest way of understanding, and expanding on, the earlier work on topos theory and quantum physics. However, the main thrust of our programme utilises the more powerful language L(S) and its representation in an appropriate topos.Comment: 36 pages, no figure