Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

On Lightweight Privacy-Preserving Collaborative Learning for IoT Objects

The Internet of Things (IoT) will be a main data generation infrastructure for achieving better system intelligence. This paper considers the design and implementation of a practical privacy-preserving collaborative learning scheme, in which a curious learning coordinator trains a better machine learning model based on the data samples contributed by a number of IoT objects, while the confidentiality of the raw forms of the training data is protected against the coordinator. Existing distributed machine learning and data encryption approaches incur significant computation and communication overhead, rendering them ill-suited for resource-constrained IoT objects. We study an approach that applies independent Gaussian random projection at each IoT object to obfuscate data and trains a deep neural network at the coordinator based on the projected data from the IoT objects. This approach introduces light computation overhead to the IoT objects and moves most workload to the coordinator that can have sufficient computing resources. Although the independent projections performed by the IoT objects address the potential collusion between the curious coordinator and some compromised IoT objects, they significantly increase the complexity of the projected data. In this paper, we leverage the superior learning capability of deep learning in capturing sophisticated patterns to maintain good learning performance. Extensive comparative evaluation shows that this approach outperforms other lightweight approaches that apply additive noisification for differential privacy and/or support vector machines for learning in the applications with light data pattern complexities.Comment: 12 pages,IOTDI 201

Machine Learning Aided Static Malware Analysis: A Survey and Tutorial

Malware analysis and detection techniques have been evolving during the last decade as a reflection to development of different malware techniques to evade network-based and host-based security protections. The fast growth in variety and number of malware species made it very difficult for forensics investigators to provide an on time response. Therefore, Machine Learning (ML) aided malware analysis became a necessity to automate different aspects of static and dynamic malware investigation. We believe that machine learning aided static analysis can be used as a methodological approach in technical Cyber Threats Intelligence (CTI) rather than resource-consuming dynamic malware analysis that has been thoroughly studied before. In this paper, we address this research gap by conducting an in-depth survey of different machine learning methods for classification of static characteristics of 32-bit malicious Portable Executable (PE32) Windows files and develop taxonomy for better understanding of these techniques. Afterwards, we offer a tutorial on how different machine learning techniques can be utilized in extraction and analysis of a variety of static characteristic of PE binaries and evaluate accuracy and practical generalization of these techniques. Finally, the results of experimental study of all the method using common data was given to demonstrate the accuracy and complexity. This paper may serve as a stepping stone for future researchers in cross-disciplinary field of machine learning aided malware forensics.Comment: 37 Page