Exploiting Nonlinear Recurrence and Fractal Scaling Properties for Voice Disorder Detection

Background: Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, and increased "breathiness". Modelling and surrogate data studies have shown significant nonlinear and non-Gaussian random properties in these sounds. Nonetheless, existing tools are limited to analysing voices displaying near periodicity, and do not account for this inherent biophysical nonlinearity and non-Gaussian randomness, often using linear signal processing methods insensitive to these properties. They do not directly measure the two main biophysical symptoms of disorder: complex nonlinear aperiodicity, and turbulent, aeroacoustic, non-Gaussian randomness. Often these tools cannot be applied to more severe disordered voices, limiting their clinical usefulness.

Methods: This paper introduces two new tools to speech analysis: recurrence and fractal scaling, which overcome the range limitations of existing tools by addressing directly these two symptoms of disorder, together reproducing a "hoarseness" diagram. A simple bootstrapped classifier then uses these two features to distinguish normal from disordered voices.

Results: On a large database of subjects with a wide variety of voice disorders, these new techniques can distinguish normal from disordered cases, using quadratic discriminant analysis, to overall correct classification performance of 91.8% plus or minus 2.0%. The true positive classification performance is 95.4% plus or minus 3.2%, and the true negative performance is 91.5% plus or minus 2.3% (95% confidence). This is shown to outperform all combinations of the most popular classical tools.

Conclusions: Given the very large number of arbitrary parameters and computational complexity of existing techniques, these new techniques are far simpler and yet achieve clinically useful classification performance using only a basic classification technique. They do so by exploiting the inherent nonlinearity and turbulent randomness in disordered voice signals. They are widely applicable to the whole range of disordered voice phenomena by design. These new measures could therefore be used for a variety of practical clinical purposes.
&#xa

Turkish /h/ deletion : evidence for the interplay of speech perception and phonology

It has been hypothesized that sounds which are less perceptible are more likely to be altered than more salient sounds, the rationale being that the loss of information resulting from a change in a sound which is difficult to perceive is not as great as the loss resulting from a change in a more salient sound. Kohler (1990) suggested that the tendency to reduce articulatory movements is countered by perceptual and social constraints, finding that fricatives are relatively resistant to reduction in colloquial German. Kohler hypothesized that this is due to the perceptual salience of fricatives, a hypothesis which was supported by the results of a perception experiment by Hura, Lindblom, and Diehl (1992). These studies showed that the relative salience of speech sounds is relevant to explaining phonological behavior. An additional factor is the impact of different acoustic environments on the perceptibility of speech sounds. Steriade (1997) found that voicing contrasts are more common in positions where more cues to voicing are available. The P-map, proposed by Steriade (2001a, b), allows the representation of varying salience of segments in different contexts. Many researchers have posited a relationship between speech perception and phonology. The purpose of this paper is to provide experimental evidence for this relationship, drawing on the case of Turkish /h/ deletion

Objective dysphonia quantification in vocal fold paralysis: comparing nonlinear with classical measures

Clinical acoustic voice recording analysis is usually performed using classical perturbation measures including jitter, shimmer and noise-to-harmonic ratios. However, restrictive mathematical limitations of these measures prevent analysis for severely dysphonic voices. Previous studies of alternative nonlinear random measures addressed wide varieties of vocal pathologies. Here, we analyze a single vocal pathology cohort, testing the performance of these alternative measures alongside classical measures.

We present voice analysis pre- and post-operatively in unilateral vocal fold paralysis (UVFP) patients and healthy controls, patients undergoing standard medialisation thyroplasty surgery, using jitter, shimmer and noise-to-harmonic ratio (NHR), and nonlinear recurrence period density entropy (RPDE), detrended fluctuation analysis (DFA) and correlation dimension. Systematizing the preparative editing of the recordings, we found that the novel measures were more stable and hence reliable, than the classical measures, on healthy controls.

RPDE and jitter are sensitive to improvements pre- to post-operation. Shimmer, NHR and DFA showed no significant change (p > 0.05). All measures detect statistically significant and clinically important differences between controls and patients, both treated and untreated (p < 0.001, AUC > 0.7). Pre- to post-operation, GRBAS ratings show statistically significant and clinically important improvement in overall dysphonia grade (G) (AUC = 0.946, p < 0.001).

Re-calculating AUCs from other study data, we compare these results in terms of clinical importance. We conclude that, when preparative editing is systematized, nonlinear random measures may be useful UVFP treatment effectiveness monitoring tools, and there may be applications for other forms of dysphonia.
&#xa

A novel framework for high-quality voice source analysis and synthesis

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The analysis, parameterization and modeling of voice source estimates obtained via inverse filtering of recorded speech are some of the most challenging areas of speech processing owing to the fact humans produce a wide range of voice source realizations and that the voice source estimates commonly contain artifacts due to the non-linear time-varying source-filter coupling. Currently, the most widely adopted representation of voice source signal is Liljencrants-Fant's (LF) model which was developed in late 1985. Due to the overly simplistic interpretation of voice source dynamics, LF model can not represent the fine temporal structure of glottal flow derivative realizations nor can it carry the sufficient spectral richness to facilitate a truly natural sounding speech synthesis. In this thesis we have introduced Characteristic Glottal Pulse Waveform Parameterization and Modeling (CGPWPM) which constitutes an entirely novel framework for voice source analysis, parameterization and reconstruction. In comparative evaluation of CGPWPM and LF model we have demonstrated that the proposed method is able to preserve higher levels of speaker dependant information from the voice source estimates and realize a more natural sounding speech synthesis. In general, we have shown that CGPWPM-based speech synthesis rates highly on the scale of absolute perceptual acceptability and that speech signals are faithfully reconstructed on consistent basis, across speakers, gender. We have applied CGPWPM to voice quality profiling and text-independent voice quality conversion method. The proposed voice conversion method is able to achieve the desired perceptual effects and the modified speech remained as natural sounding and intelligible as natural speech. In this thesis, we have also developed an optimal wavelet thresholding strategy for voice source signals which is able to suppress aspiration noise and still retain both the slow and the rapid variations in the voice source estimate

Analysis and Detection of Pathological Voice using Glottal Source Features

Automatic detection of voice pathology enables objective assessment and earlier intervention for the diagnosis. This study provides a systematic analysis of glottal source features and investigates their effectiveness in voice pathology detection. Glottal source features are extracted using glottal flows estimated with the quasi-closed phase (QCP) glottal inverse filtering method, using approximate glottal source signals computed with the zero frequency filtering (ZFF) method, and using acoustic voice signals directly. In addition, we propose to derive mel-frequency cepstral coefficients (MFCCs) from the glottal source waveforms computed by QCP and ZFF to effectively capture the variations in glottal source spectra of pathological voice. Experiments were carried out using two databases, the Hospital Universitario Principe de Asturias (HUPA) database and the Saarbrucken Voice Disorders (SVD) database. Analysis of features revealed that the glottal source contains information that discriminates normal and pathological voice. Pathology detection experiments were carried out using support vector machine (SVM). From the detection experiments it was observed that the performance achieved with the studied glottal source features is comparable or better than that of conventional MFCCs and perceptual linear prediction (PLP) features. The best detection performance was achieved when the glottal source features were combined with the conventional MFCCs and PLP features, which indicates the complementary nature of the features

Models and Analysis of Vocal Emissions for Biomedical Applications

The MAVEBA Workshop proceedings, held on a biannual basis, collect the scientific papers presented both as oral and poster contributions, during the conference. The main subjects are: development of theoretical and mechanical models as an aid to the study of main phonatory dysfunctions, as well as the biomedical engineering methods for the analysis of voice signals and images, as a support to clinical diagnosis and classification of vocal pathologies

Implementation of ultrasonic sensing for high resolution measurement of binary gas mixture fractions

We describe an ultrasonic instrument for continuous real-time analysis of the fractional mixture of a binary gas system. The instrument is particularly well suited to measurement of leaks of a high molecular weight gas into a system that is nominally composed of a single gas. Sensitivity < 5 × 10−5 is demonstrated to leaks of octaflouropropane (C3F8) coolant into nitrogen during a long duration (18 month) continuous study. The sensitivity of the described measurement system is shown to depend on the difference in molecular masses of the two gases in the mixture. The impact of temperature and pressure variances on the accuracy of the measurement is analysed. Practical considerations for the implementation and deployment of long term, in situ ultrasonic leak detection systems are also described. Although development of the described systems was motivated by the requirements of an evaporative fluorocarbon cooling system, the instrument is applicable to the detection of leaks of many other gases and to processes requiring continuous knowledge of particular binary gas mixture fractions