4,269 research outputs found
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
Keypoint Transfer for Fast Whole-Body Segmentation
We introduce an approach for image segmentation based on sparse
correspondences between keypoints in testing and training images. Keypoints
represent automatically identified distinctive image locations, where each
keypoint correspondence suggests a transformation between images. We use these
correspondences to transfer label maps of entire organs from the training
images to the test image. The keypoint transfer algorithm includes three steps:
(i) keypoint matching, (ii) voting-based keypoint labeling, and (iii)
keypoint-based probabilistic transfer of organ segmentations. We report
segmentation results for abdominal organs in whole-body CT and MRI, as well as
in contrast-enhanced CT and MRI. Our method offers a speed-up of about three
orders of magnitude in comparison to common multi-atlas segmentation, while
achieving an accuracy that compares favorably. Moreover, keypoint transfer does
not require the registration to an atlas or a training phase. Finally, the
method allows for the segmentation of scans with highly variable field-of-view.Comment: Accepted for publication at IEEE Transactions on Medical Imagin
Ball-Scale Based Hierarchical Multi-Object Recognition in 3D Medical Images
This paper investigates, using prior shape models and the concept of ball
scale (b-scale), ways of automatically recognizing objects in 3D images without
performing elaborate searches or optimization. That is, the goal is to place
the model in a single shot close to the right pose (position, orientation, and
scale) in a given image so that the model boundaries fall in the close vicinity
of object boundaries in the image. This is achieved via the following set of
key ideas: (a) A semi-automatic way of constructing a multi-object shape model
assembly. (b) A novel strategy of encoding, via b-scale, the pose relationship
between objects in the training images and their intensity patterns captured in
b-scale images. (c) A hierarchical mechanism of positioning the model, in a
one-shot way, in a given image from a knowledge of the learnt pose relationship
and the b-scale image of the given image to be segmented. The evaluation
results on a set of 20 routine clinical abdominal female and male CT data sets
indicate the following: (1) Incorporating a large number of objects improves
the recognition accuracy dramatically. (2) The recognition algorithm can be
thought as a hierarchical framework such that quick replacement of the model
assembly is defined as coarse recognition and delineation itself is known as
finest recognition. (3) Scale yields useful information about the relationship
between the model assembly and any given image such that the recognition
results in a placement of the model close to the actual pose without doing any
elaborate searches or optimization. (4) Effective object recognition can make
delineation most accurate.Comment: This paper was published and presented in SPIE Medical Imaging 201
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