46,838 research outputs found
Automated Quantification of White Blood Cells in Light Microscopic Images of Injured Skeletal Muscle
Muscle regeneration process tracking and analysis aim to monitor the injured muscle tissue section over time and analyze the muscle healing procedure. In this procedure, as one of the most diverse cell types observed, white blood cells (WBCs) exhibit dynamic cellular response and undergo multiple protein expression changes. The characteristics, amount, location, and distribution compose the action of cells which may change over time. Their actions and relationships over the whole healing procedure can be analyzed by processing the microscopic images taken at different time points after injury. The previous studies of muscle regeneration usually employ manual approach or basic intensity process to detect and count WBCs. In comparison, computer vision method is more promising in accuracy, processing speed, and labor cost. Besides, it can extract features like cell/cluster size and eccentricity fast and accurately.
In this thesis, we propose an automated quantifying and analysis framework to analyze the WBC in light microscope images of uninjured and injured skeletal muscles. The proposed framework features a hybrid image segmentation method combining the Localized Iterative Otsu’s threshold method assisted by neural networks classifiers and muscle edge detection. In specific, both neural network and convoluted neural network based classifiers are studied and compared. Via this framework, the CD68-positive WBC and 7/4-positive WBC quantification and density distribution results are analyzed for demonstrating the effectiveness of the proposed method
Popular Ensemble Methods: An Empirical Study
An ensemble consists of a set of individually trained classifiers (such as
neural networks or decision trees) whose predictions are combined when
classifying novel instances. Previous research has shown that an ensemble is
often more accurate than any of the single classifiers in the ensemble. Bagging
(Breiman, 1996c) and Boosting (Freund and Shapire, 1996; Shapire, 1990) are two
relatively new but popular methods for producing ensembles. In this paper we
evaluate these methods on 23 data sets using both neural networks and decision
trees as our classification algorithm. Our results clearly indicate a number of
conclusions. First, while Bagging is almost always more accurate than a single
classifier, it is sometimes much less accurate than Boosting. On the other
hand, Boosting can create ensembles that are less accurate than a single
classifier -- especially when using neural networks. Analysis indicates that
the performance of the Boosting methods is dependent on the characteristics of
the data set being examined. In fact, further results show that Boosting
ensembles may overfit noisy data sets, thus decreasing its performance.
Finally, consistent with previous studies, our work suggests that most of the
gain in an ensemble's performance comes in the first few classifiers combined;
however, relatively large gains can be seen up to 25 classifiers when Boosting
decision trees
An Overview of Classifier Fusion Methods
A number of classifier fusion methods have been
recently developed opening an alternative approach
leading to a potential improvement in the
classification performance. As there is little theory of
information fusion itself, currently we are faced with
different methods designed for different problems and
producing different results. This paper gives an
overview of classifier fusion methods and attempts to
identify new trends that may dominate this area of
research in future. A taxonomy of fusion methods
trying to bring some order into the existing “pudding
of diversities” is also provided
Linear and Order Statistics Combiners for Pattern Classification
Several researchers have experimentally shown that substantial improvements
can be obtained in difficult pattern recognition problems by combining or
integrating the outputs of multiple classifiers. This chapter provides an
analytical framework to quantify the improvements in classification results due
to combining. The results apply to both linear combiners and order statistics
combiners. We first show that to a first order approximation, the error rate
obtained over and above the Bayes error rate, is directly proportional to the
variance of the actual decision boundaries around the Bayes optimum boundary.
Combining classifiers in output space reduces this variance, and hence reduces
the "added" error. If N unbiased classifiers are combined by simple averaging,
the added error rate can be reduced by a factor of N if the individual errors
in approximating the decision boundaries are uncorrelated. Expressions are then
derived for linear combiners which are biased or correlated, and the effect of
output correlations on ensemble performance is quantified. For order statistics
based non-linear combiners, we derive expressions that indicate how much the
median, the maximum and in general the ith order statistic can improve
classifier performance. The analysis presented here facilitates the
understanding of the relationships among error rates, classifier boundary
distributions, and combining in output space. Experimental results on several
public domain data sets are provided to illustrate the benefits of combining
and to support the analytical results.Comment: 31 page
Combining Parametric and Non-parametric Algorithms for a Partially Unsupervised Classification of Multitemporal Remote-Sensing Images
In this paper, we propose a classification system based on a multiple-classifier architecture, which is aimed at updating land-cover maps by using multisensor and/or multisource remote-sensing images. The proposed system is composed of an ensemble of classifiers that, once trained in a supervised way on a specific image of a given area, can be retrained in an unsupervised way to classify a new image of the considered site. In this context, two techniques are presented for the unsupervised updating of the parameters of a maximum-likelihood (ML) classifier and a radial basis function (RBF) neural-network classifier, on the basis of the distribution of the new image to be classified. Experimental results carried out on a multitemporal and multisource remote-sensing data set confirm the effectiveness of the proposed system
An Overview of Classifier Fusion Methods
A number of classifier fusion methods have been
recently developed opening an alternative approach
leading to a potential improvement in the
classification performance. As there is little theory of
information fusion itself, currently we are faced with
different methods designed for different problems and
producing different results. This paper gives an
overview of classifier fusion methods and attempts to
identify new trends that may dominate this area of
research in future. A taxonomy of fusion methods
trying to bring some order into the existing “pudding
of diversities” is also provided
One-Class Classification: Taxonomy of Study and Review of Techniques
One-class classification (OCC) algorithms aim to build classification models
when the negative class is either absent, poorly sampled or not well defined.
This unique situation constrains the learning of efficient classifiers by
defining class boundary just with the knowledge of positive class. The OCC
problem has been considered and applied under many research themes, such as
outlier/novelty detection and concept learning. In this paper we present a
unified view of the general problem of OCC by presenting a taxonomy of study
for OCC problems, which is based on the availability of training data,
algorithms used and the application domains applied. We further delve into each
of the categories of the proposed taxonomy and present a comprehensive
literature review of the OCC algorithms, techniques and methodologies with a
focus on their significance, limitations and applications. We conclude our
paper by discussing some open research problems in the field of OCC and present
our vision for future research.Comment: 24 pages + 11 pages of references, 8 figure
Learning Hybrid Neuro-Fuzzy Classifier Models From Data: To Combine or Not to Combine?
To combine or not to combine? Though not a question of the same gravity as the Shakespeare’s to be or not
to be, it is examined in this paper in the context of a hybrid neuro-fuzzy pattern classifier design process. A general fuzzy
min-max neural network with its basic learning procedure is used within six different algorithm independent learning
schemes. Various versions of cross-validation, resampling techniques and data editing approaches, leading to a generation
of a single classifier or a multiple classifier system, are scrutinised and compared. The classification performance on
unseen data, commonly used as a criterion for comparing different competing designs, is augmented by further four
criteria attempting to capture various additional characteristics of classifier generation schemes. These include: the ability
to estimate the true classification error rate, the classifier transparency, the computational complexity of the learning
scheme and the potential for adaptation to changing environments and new classes of data. One of the main questions
examined is whether and when to use a single classifier or a combination of a number of component classifiers within a
multiple classifier system
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