Smart Sensors for Healthcare and Medical Applications

This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare

Computer aided assessment of CT scans of traumatic brain injury patients

A thesis submitted in partial fulfilment for the degree of Doctor of PhilosophyOne of the serious public health problems is the Traumatic Brain Injury, also known as silent epidemic, affecting millions every year. Management of these patients essentially involves neuroimaging and noncontrast CT scans are the first choice amongst doctors. Significant anatomical changes identified on the neuroimages and volumetric assessment of haemorrhages and haematomas are of critical importance for assessing the patients’ condition for targeted therapeutic and/or surgical interventions. Manual demarcation and annotation by experts is still considered gold standard, however, the interpretation of neuroimages is fraught with inter-observer variability and is considered ’Achilles heel’ amongst radiologists. Errors and variability can be attributed to factors such as poor perception, inaccurate deduction, incomplete knowledge or the quality of the image and only a third of doctors confidently report the findings. The applicability of computer aided dianosis in segmenting the apposite regions and giving ’second opinion’ has been positively appraised to assist the radiologists, however, results of the approaches vary due to parameters of algorithms and manual intervention required from doctors and this presents a gap for automated segmentation and estimation of measurements of noncontrast brain CT scans. The Pattern Driven, Content Aware Active Contours (PDCAAC) Framework developed in this thesis provides robust and efficient segmentation of significant anatomical landmarks, estimations of their sizes and correlation to CT rating to assist the radiologists in establishing the diagnosis and prognosis more confidently. The integration of clinical profile of the patient into image segmentation algorithms has significantly improved their performance by highlighting characteristics of the region of interest. The modified active contour method in the PDCAAC framework achieves Jaccard Similarity Index (JI) of 0.87, which is a significant improvement over the existing methods of active contours achieving JI of 0.807 with Simple Linear Iterative Clustering and Distance Regularized Level Set Evolution. The Intraclass Correlation Coefficient of intracranial measurements is >0.97 compared with radiologists. Automatic seeding of the initial seed curve within the region of interest is incorporated into the method which is a novel approach and alleviates limitation of existing methods. The proposed PDCAAC framework can be construed as a contribution towards research to formulate correlations between image features and clinical variables encompassing normal development, ageing, pathological and traumatic cases propitious to improve management of such patients. Establishing prognosis usually entails survival but the focus can also be extended to functional outcomes, residual disability and quality of life issues

Ultra-low power IoT applications: from transducers to wireless protocols

This dissertation aims to explore Internet of Things (IoT) sensor nodes in various application scenarios with different design requirements. The research provides a comprehensive exploration of all the IoT layers composing an advanced device, from transducers to on-board processing, through low power hardware schemes and wireless protocols for wide area networks. Nowadays, spreading and massive utilization of wireless sensor nodes pushes research and industries to overcome the main limitations of such constrained devices, aiming to make them easily deployable at a lower cost. Significant challenges involve the battery lifetime that directly affects the device operativity and the wireless communication bandwidth. Factors that commonly contrast the system scalability and the energy per bit, as well as the maximum coverage. This thesis aims to serve as a reference and guideline document for future IoT projects, where results are structured following a conventional development pipeline. They usually consider communication standards and sensing as project requirements and low power operation as a necessity. A detailed overview of five leading IoT wireless protocols, together with custom solutions to overcome the throughput limitations and decrease the power consumption, are some of the topic discussed. Low power hardware engineering in multiple applications is also introduced, especially focusing on improving the trade-off between energy, functionality, and on-board processing capabilities. To enhance these features and to provide a bottom-top overview of an IoT sensor node, an innovative and low-cost transducer for structural health monitoring is presented. Lastly, the high-performance computing at the extreme edge of the IoT framework is addressed, with special attention to image processing algorithms running on state of the art RISC-V architecture. As a specific deployment scenario, an OpenCV-based stack, together with a convolutional neural network, is assessed on the octa-core PULP SoC