SUBIC: A Supervised Bi-Clustering Approach for Precision Medicine

Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researchers to develop new approaches to subgroup detection and analysis, which is an effective strategy to personalize treatment. In this study, we propose a novel patient subgroup detection method, called Supervised Biclustring (SUBIC) using convex optimization and apply our approach to detect patient subgroups and prioritize risk factors for hypertension (HTN) in a vulnerable demographic subgroup (African-American). Our approach not only finds patient subgroups with guidance of a clinically relevant target variable but also identifies and prioritizes risk factors by pursuing sparsity of the input variables and encouraging similarity among the input variables and between the input and target variable

Greedy Methods in Plume Detection, Localization and Tracking

Greedy method, as an efficient computing tool, can be applied to various combinatorial or nonlinear optimization problems where finding the global optimum is difficult, if not computationally infeasible. A greedy algorithm has the nature of making the locally optimal choice at each stage and then solving the subproblems that arise later. It iteratively make

Feature Representation for Online Signature Verification

Biometrics systems have been used in a wide range of applications and have improved people authentication. Signature verification is one of the most common biometric methods with techniques that employ various specifications of a signature. Recently, deep learning has achieved great success in many fields, such as image, sounds and text processing. In this paper, deep learning method has been used for feature extraction and feature selection.Comment: 10 pages, 10 figures, Submitted to IEEE Transactions on Information Forensics and Securit

Automated design of robust discriminant analysis classifier for foot pressure lesions using kinematic data

In the recent years, the use of motion tracking systems for acquisition of functional biomechanical gait data, has received increasing interest due to the richness and accuracy of the measured kinematic information. However, costs frequently restrict the number of subjects employed, and this makes the dimensionality of the collected data far higher than the available samples. This paper applies discriminant analysis algorithms to the classification of patients with different types of foot lesions, in order to establish an association between foot motion and lesion formation. With primary attention to small sample size situations, we compare different types of Bayesian classifiers and evaluate their performance with various dimensionality reduction techniques for feature extraction, as well as search methods for selection of raw kinematic variables. Finally, we propose a novel integrated method which fine-tunes the classifier parameters and selects the most relevant kinematic variables simultaneously. Performance comparisons are using robust resampling techniques such as Bootstrap$632+$and k-fold cross-validation. Results from experimentations with lesion subjects suffering from pathological plantar hyperkeratosis, show that the proposed method can lead to$sim 96$correct classification rates with less than 10% of the original features

Harnessing heterogeneous social networks for better recommendations: A grey relational analysis approach

Most of the extant studies in social recommender system are based on explicit social relationships, while the potential of implicit relationships in the heterogeneous social networks remains largely unexplored. This study proposes a new approach to designing a recommender system by employing grey relational analysis on the heterogeneous social networks. It starts with the establishment of heterogeneous social networks through the user-item bipartite graph, user social network graph and user-attribute bipartite graph; and then uses grey relational analysis to identify implicit social relationships, which are then incorporated into the matrix factorization model. Five experiments were conducted to test the performance of our approach against four state-of-the-art baseline methods. The results show that compared with the baseline methods, our approach can effectively alleviate the sparsity problem, because the heterogeneous social network provides richer information. In addition, the grey relational analysis method has the advantage of low requirements for data size and efficiently relieves the cold start problem. Furthermore, our approach saves processing time, thus increases recommendation efficiency. Overall, the proposed approach can effectively improve the accuracy of rating prediction in social recommendations and provide accurate and efficient recommendation service for users