Medical data mining using Bayesian network and DNA sequence analysis.

Lee Kit Ying.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.Includes bibliographical references (leaves 115-117).Abstracts in English and Chinese.Abstract --- p.iAcknowledgement --- p.ivChapter 1 --- Introduction --- p.1Chapter 1.1 --- Project Background --- p.1Chapter 1.2 --- Problem Specifications --- p.3Chapter 1.3 --- Contributions --- p.5Chapter 1.4 --- Thesis Organization --- p.6Chapter 2 --- Background --- p.8Chapter 2.1 --- Medical Data Mining --- p.8Chapter 2.1.1 --- General Information --- p.9Chapter 2.1.2 --- Related Research --- p.10Chapter 2.1.3 --- Characteristics and Difficulties Encountered --- p.11Chapter 2.2 --- DNA Sequence Analysis --- p.13Chapter 2.3 --- Hepatitis B Virus --- p.14Chapter 2.3.1 --- Virus Characteristics --- p.15Chapter 2.3.2 --- Important Findings on the Virus --- p.17Chapter 2.4 --- Bayesian Network and its Classifiers --- p.17Chapter 2.4.1 --- Formal Definition --- p.18Chapter 2.4.2 --- Existing Learning Algorithms --- p.19Chapter 2.4.3 --- Evolutionary Algorithms and Hybrid EP (HEP) --- p.22Chapter 2.4.4 --- Bayesian Network Classifiers --- p.25Chapter 2.4.5 --- Learning Algorithms for BN Classifiers --- p.32Chapter 3 --- Bayesian Network Classifier for Clinical Data --- p.35Chapter 3.1 --- Related Work --- p.36Chapter 3.2 --- Proposed BN-augmented Naive Bayes Classifier (BAN) --- p.38Chapter 3.2.1 --- Definition --- p.38Chapter 3.2.2 --- Learning Algorithm with HEP --- p.39Chapter 3.2.3 --- Modifications on HEP --- p.39Chapter 3.3 --- Proposed General Bayesian Network with Markov Blan- ket (GBN) --- p.40Chapter 3.3.1 --- Definition --- p.41Chapter 3.3.2 --- Learning Algorithm with HEP --- p.41Chapter 3.4 --- Findings on Bayesian Network Parameters Calculation --- p.43Chapter 3.4.1 --- Situation and Errors --- p.43Chapter 3.4.2 --- Proposed Solution --- p.46Chapter 3.5 --- Performance Analysis on Proposed BN Classifier Learn- ing Algorithms --- p.47Chapter 3.5.1 --- Experimental Methodology --- p.47Chapter 3.5.2 --- Benchmark Data --- p.48Chapter 3.5.3 --- Clinical Data --- p.50Chapter 3.5.4 --- Discussion --- p.55Chapter 3.6 --- Summary --- p.56Chapter 4 --- Classification in DNA Analysis --- p.57Chapter 4.1 --- Related Work --- p.58Chapter 4.2 --- Problem Definition --- p.59Chapter 4.3 --- Proposed Methodology Architecture --- p.60Chapter 4.3.1 --- Overall Design --- p.60Chapter 4.3.2 --- Important Components --- p.62Chapter 4.4 --- Clustering --- p.63Chapter 4.5 --- Feature Selection Algorithms --- p.65Chapter 4.5.1 --- Information Gain --- p.66Chapter 4.5.2 --- Other Approaches --- p.67Chapter 4.6 --- Classification Algorithms --- p.67Chapter 4.6.1 --- Naive Bayes Classifier --- p.68Chapter 4.6.2 --- Decision Tree --- p.68Chapter 4.6.3 --- Neural Networks --- p.68Chapter 4.6.4 --- Other Approaches --- p.69Chapter 4.7 --- Important Points on Evaluation --- p.69Chapter 4.7.1 --- Errors --- p.70Chapter 4.7.2 --- Independent Test --- p.70Chapter 4.8 --- Performance Analysis on Classification of DNA Data --- p.71Chapter 4.8.1 --- Experimental Methodology --- p.71Chapter 4.8.2 --- Using Naive-Bayes Classifier --- p.73Chapter 4.8.3 --- Using Decision Tree --- p.73Chapter 4.8.4 --- Using Neural Network --- p.74Chapter 4.8.5 --- Discussion --- p.76Chapter 4.9 --- Summary --- p.77Chapter 5 --- Adaptive HEP for Learning Bayesian Network Struc- ture --- p.78Chapter 5.1 --- Background --- p.79Chapter 5.1.1 --- Objective --- p.79Chapter 5.1.2 --- Related Work - AEGA --- p.79Chapter 5.2 --- Feasibility Study --- p.80Chapter 5.3 --- Proposed A-HEP Algorithm --- p.82Chapter 5.3.1 --- Structural Dissimilarity Comparison --- p.82Chapter 5.3.2 --- Dynamic Population Size --- p.83Chapter 5.4 --- Evaluation on Proposed Algorithm --- p.88Chapter 5.4.1 --- Experimental Methodology --- p.89Chapter 5.4.2 --- Comparison on Running Time --- p.93Chapter 5.4.3 --- Comparison on Fitness of Final Network --- p.94Chapter 5.4.4 --- Comparison on Similarity to the Original Network --- p.95Chapter 5.4.5 --- Parameter Study --- p.96Chapter 5.5 --- Applications on Medical Domain --- p.100Chapter 5.5.1 --- Discussion --- p.100Chapter 5.5.2 --- An Example --- p.101Chapter 5.6 --- Summary --- p.105Chapter 6 --- Conclusion --- p.107Chapter 6.1 --- Summary --- p.107Chapter 6.2 --- Future Work --- p.109Bibliography --- p.11