A Road Network Selection Process Based on Data Enrichment and Structure Detection

International audienceIn the context of geographical database generalisation, this paper deals with a generic process for road network selection. It is based on the geographical context that is made explicit and on the characteristic structure preservation. It relies on literature work that is adapted and gathered. The first step is to detect significant structures and patterns of the road network such as roundabouts or highway interchanges. It allows to enrich the initial dataset with explicit geographic structures that were implicit in initial data. It helps both to explicit the geographical context and to preserve characteristic structures. Then, this enrichment is used as knowledge input for the following step that is the selection of roads in rural areas using graph theory techniques. After that, urban roads are selected by means of a block aggregation complex algorithm. Continuity between urban and rural areas is guaranteed by modelling continuity using strokes. Finally, the previously detected characteristic structures are typified to maintain their properties in the selected network. This automated process has been fully implemented on Clarity™ and tested on large datasets

When Things Matter: A Data-Centric View of the Internet of Things

With the recent advances in radio-frequency identification (RFID), low-cost wireless sensor devices, and Web technologies, the Internet of Things (IoT) approach has gained momentum in connecting everyday objects to the Internet and facilitating machine-to-human and machine-to-machine communication with the physical world. While IoT offers the capability to connect and integrate both digital and physical entities, enabling a whole new class of applications and services, several significant challenges need to be addressed before these applications and services can be fully realized. A fundamental challenge centers around managing IoT data, typically produced in dynamic and volatile environments, which is not only extremely large in scale and volume, but also noisy, and continuous. This article surveys the main techniques and state-of-the-art research efforts in IoT from data-centric perspectives, including data stream processing, data storage models, complex event processing, and searching in IoT. Open research issues for IoT data management are also discussed

Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks

Cellular senescence is a barrier to tumorigenesis in normal cells and tumour cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common with apoptosis the dominant effect. Hence, more selective senescence inducers are required. Here we report a machine learning-based in silico screen to identify potential senescence agonists. We built profiles of differentially affected biological process networks from expression data obtained under induced telomere dysfunction conditions in colorectal cancer cells and matched these to a panel of 17 protein targets with confirmatory screening data in PubChem. We trained a neural network using 3517 compounds identified as active or inactive against these targets. The resulting classification model was used to screen a virtual library of ~2M lead-like compounds. 147 virtual hits were acquired for validation in growth inhibition and senescence-associated β-galactosidase (SA-β-gal) assays. Among the found hits a benzimidazolone compound, CB-20903630, had low micromolar IC50 for growth inhibition of HCT116 cells and selectively induced SA-β-gal activity in the entire treated cell population without cytotoxicity or apoptosis induction. Growth suppression was mediated by G1 blockade involving increased p21 expression and suppressed cyclin B1, CDK1 and CDC25C. Additionally, the compound inhibited growth of multicellular spheroids and caused severe retardation of population kinetics in long term treatments. Preliminary structure-activity and structure clustering analyses are reported and expression analysis of CB-20903630 against other cell cycle suppressor compounds suggested a PI3K/AKT-inhibitor-like profile in normal cells, with different pathways affected in cancer cells

Deep Learning for Enrichment of Vector Spatial Databases: Application to Highway Interchange

Spatial analysis and pattern recognition with vector spatial data is particularly useful to enrich raw data. In road networks for instance, there are many patterns and structures that are implicit with only road line features, among which highway interchange appeared very complex to recognise with vector-based techniques. The goal is to find the roads that belong to an interchange, i.e. the slip roads and the highway roads connected to the slip roads. In order to go further than state-of-the-art vector-based techniques, this paper proposes to use raster-based deep learning techniques to recognise highway interchanges. The contribution of this work is to study how to optimally convert vector data into small images suitable for state-of-the-art deep learning models. Image classification with a convolutional neural network (i.e. is there an interchange in this image or not?) and image segmentation with a u-net (i.e. find the pixels that cover the interchange) are experimented and give results way better than existing vector-based techniques in this specific use case

Patient-centric trials for therapeutic development in precision oncology

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine

Updates in metabolomics tools and resources: 2014-2015

Data processing and interpretation represent the most challenging and time-consuming steps in high-throughput metabolomic experiments, regardless of the analytical platforms (MS or NMR spectroscopy based) used for data acquisition. Improved machinery in metabolomics generates increasingly complex datasets that create the need for more and better processing and analysis software and in silico approaches to understand the resulting data. However, a comprehensive source of information describing the utility of the most recently developed and released metabolomics resources—in the form of tools, software, and databases—is currently lacking. Thus, here we provide an overview of freely-available, and open-source, tools, algorithms, and frameworks to make both upcoming and established metabolomics researchers aware of the recent developments in an attempt to advance and facilitate data processing workflows in their metabolomics research. The major topics include tools and researches for data processing, data annotation, and data visualization in MS and NMR-based metabolomics. Most in this review described tools are dedicated to untargeted metabolomics workflows; however, some more specialist tools are described as well. All tools and resources described including their analytical and computational platform dependencies are summarized in an overview Table