25,599 research outputs found
Sam2bam: High-Performance Framework for NGS Data Preprocessing Tools
This paper introduces a high-throughput software tool framework called {\it
sam2bam} that enables users to significantly speedup pre-processing for
next-generation sequencing data. The sam2bam is especially efficient on
single-node multi-core large-memory systems. It can reduce the runtime of data
pre-processing in marking duplicate reads on a single node system by 156-186x
compared with de facto standard tools. The sam2bam consists of parallel
software components that can fully utilize the multiple processors, available
memory, high-bandwidth of storage, and hardware compression accelerators if
available.
The sam2bam provides file format conversion between well-known genome file
formats, from SAM to BAM, as a basic feature. Additional features such as
analyzing, filtering, and converting the input data are provided by {\it
plug-in} tools, e.g., duplicate marking, which can be attached to sam2bam at
runtime.
We demonstrated that sam2bam could significantly reduce the runtime of NGS
data pre-processing from about two hours to about one minute for a whole-exome
data set on a 16-core single-node system using up to 130 GB of memory. The
sam2bam could reduce the runtime for whole-genome sequencing data from about 20
hours to about nine minutes on the same system using up to 711 GB of memory
Beam Loss Monitors at LHC
One of the main functions of the LHC beam loss measurement system is the
protection of equipment against damage caused by impacting particles creating
secondary showers and their energy dissipation in the matter. Reliability
requirements are scaled according to the acceptable consequences and the
frequency of particle impact events on equipment. Increasing reliability often
leads to more complex systems. The downside of complexity is a reduction of
availability; therefore, an optimum has to be found for these conflicting
requirements. A detailed review of selected concepts and solutions for the LHC
system will be given to show approaches used in various parts of the system
from the sensors, signal processing, and software implementations to the
requirements for operation and documentation.Comment: 16 pages, contribution to the 2014 Joint International Accelerator
School: Beam Loss and Accelerator Protection, Newport Beach, CA, USA , 5-14
Nov 201
Controls and Interfaces
Reliable powering of accelerator magnets requires reliable power converters
and controls, able to meet the powering specifications in the long term. In
this paper, some of the issues that will challenge a power converter controls
engineer are discussed.Comment: 16 pages, contribution to the 2014 CAS - CERN Accelerator School:
Power Converters, Baden, Switzerland, 7-14 May 201
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