3,564 research outputs found
Non-Gaussian Discriminative Factor Models via the Max-Margin Rank-Likelihood
We consider the problem of discriminative factor analysis for data that are
in general non-Gaussian. A Bayesian model based on the ranks of the data is
proposed. We first introduce a new {\em max-margin} version of the
rank-likelihood. A discriminative factor model is then developed, integrating
the max-margin rank-likelihood and (linear) Bayesian support vector machines,
which are also built on the max-margin principle. The discriminative factor
model is further extended to the {\em nonlinear} case through mixtures of local
linear classifiers, via Dirichlet processes. Fully local conjugacy of the model
yields efficient inference with both Markov Chain Monte Carlo and variational
Bayes approaches. Extensive experiments on benchmark and real data demonstrate
superior performance of the proposed model and its potential for applications
in computational biology.Comment: 14 pages, 7 figures, ICML 201
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
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