23,855 research outputs found
Rust-Bio - a fast and safe bioinformatics library
We present Rust-Bio, the first general purpose bioinformatics library for the
innovative Rust programming language. Rust-Bio leverages the unique combination
of speed, memory safety and high-level syntax offered by Rust to provide a fast
and safe set of bioinformatics algorithms and data structures with a focus on
sequence analysis
Chemoinformatics Research at the University of Sheffield: A History and Citation Analysis
This paper reviews the work of the Chemoinformatics Research Group in the Department of Information Studies at the University of Sheffield, focusing particularly on the work carried out in the period 1985-2002. Four major research areas are discussed, these involving the development of methods for: substructure searching in databases of three-dimensional structures, including both rigid and flexible molecules; the representation and searching of the Markush structures that occur in chemical patents; similarity searching in databases of both two-dimensional and three-dimensional structures; and compound selection and the design of combinatorial libraries. An analysis of citations to 321 publications from the Group shows that it attracted a total of 3725 residual citations during the period 1980-2002. These citations appeared in 411 different journals, and involved 910 different citing organizations from 54 different countries, thus demonstrating the widespread impact of the Group's work
Enumerating Maximal Bicliques from a Large Graph using MapReduce
We consider the enumeration of maximal bipartite cliques (bicliques) from a
large graph, a task central to many practical data mining problems in social
network analysis and bioinformatics. We present novel parallel algorithms for
the MapReduce platform, and an experimental evaluation using Hadoop MapReduce.
Our algorithm is based on clustering the input graph into smaller sized
subgraphs, followed by processing different subgraphs in parallel. Our
algorithm uses two ideas that enable it to scale to large graphs: (1) the
redundancy in work between different subgraph explorations is minimized through
a careful pruning of the search space, and (2) the load on different reducers
is balanced through the use of an appropriate total order among the vertices.
Our evaluation shows that the algorithm scales to large graphs with millions of
edges and tens of mil- lions of maximal bicliques. To our knowledge, this is
the first work on maximal biclique enumeration for graphs of this scale.Comment: A preliminary version of the paper was accepted at the Proceedings of
the 3rd IEEE International Congress on Big Data 201
Distributed BLAST in a grid computing context
The Basic Local Alignment Search Tool (BLAST) is one of the best known sequence comparison programs available in bioinformatics. It is used to compare query sequences to a set of target sequences, with the intention of finding similar sequences in the target set. Here, we present a distributed BLAST service which operates over a set of heterogeneous Grid resources and is made available through a Globus toolkit v.3 Grid service. This work has been carried out in the context of the BRIDGES project, a UK e-Science project aimed at providing a Grid based environment for biomedical research. Input consisting of multiple query sequences is partitioned into sub-jobs on the basis of the number of idle compute nodes available and then processed on these in batches. To achieve this, we have implemented our own Java-based scheduler which distributes sub-jobs across an array of resources utilizing a variety of local job scheduling systems
Supervised cross-modal factor analysis for multiple modal data classification
In this paper we study the problem of learning from multiple modal data for
purpose of document classification. In this problem, each document is composed
two different modals of data, i.e., an image and a text. Cross-modal factor
analysis (CFA) has been proposed to project the two different modals of data to
a shared data space, so that the classification of a image or a text can be
performed directly in this space. A disadvantage of CFA is that it has ignored
the supervision information. In this paper, we improve CFA by incorporating the
supervision information to represent and classify both image and text modals of
documents. We project both image and text data to a shared data space by factor
analysis, and then train a class label predictor in the shared space to use the
class label information. The factor analysis parameter and the predictor
parameter are learned jointly by solving one single objective function. With
this objective function, we minimize the distance between the projections of
image and text of the same document, and the classification error of the
projection measured by hinge loss function. The objective function is optimized
by an alternate optimization strategy in an iterative algorithm. Experiments in
two different multiple modal document data sets show the advantage of the
proposed algorithm over other CFA methods
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