A dynamic latent variable model for source separation

We propose a novel latent variable model for learning latent bases for time-varying non-negative data. Our model uses a mixture multinomial as the likelihood function and proposes a Dirichlet distribution with dynamic parameters as a prior, which we call the dynamic Dirichlet prior. An expectation maximization (EM) algorithm is developed for estimating the parameters of the proposed model. Furthermore, we connect our proposed dynamic Dirichlet latent variable model (dynamic DLVM) to the two popular latent basis learning methods - probabilistic latent component analysis (PLCA) and non-negative matrix factorization (NMF). We show that (i) PLCA is a special case of the dynamic DLVM, and (ii) dynamic DLVM can be interpreted as a dynamic version of NMF. The effectiveness of the proposed model is demonstrated through extensive experiments on speaker source separation, and speech-noise separation. In both cases, our method performs better than relevant and competitive baselines. For speaker separation, dynamic DLVM shows 1.38 dB improvement in terms of source to interference ratio, and 1 dB improvement in source to artifact ratio

Dirichlet latent variable model : a dynamic model based on Dirichlet prior for audio processing

We propose a dynamic latent variable model for learning latent bases from time varying, non-negative data. We take a probabilistic approach to modeling the temporal dependence in data by introducing a dynamic Dirichlet prior – a Dirichlet distribution with dynamic parameters. This new distribution allows us to assure non-negativity and avoid intractability when sequential updates are performed (otherwise encountered in using Dirichlet prior). We refer to the proposed model as the Dirichlet latent variable model (DLVM). We develop an expectation maximization algorithm for the proposed model, and also derive a maximum a posteriori estimate of the parameters. Furthermore, we connect the proposed DLVM to two popular latent basis learning methods - probabilistic latent component analysis (PLCA) and non-negative matrix factorization (NMF).We show that (i) PLCA is a special case of our DLVM, and (ii) DLVM can be interpreted as a dynamic version of NMF. The usefulness of DLVM is demonstrated for three audio processing applications - speaker source separation, denoising, and bandwidth expansion. To this end, a new algorithm for source separation is also proposed. Through extensive experiments on benchmark databases, we show that the proposed model out performs several relevant existing methods in all three applications

Advanced source separation methods with applications to spatio-temporal datasets

Latent variable models are useful tools for statistical data analysis in many applications. Examples of popular models include factor analysis, state-space models and independent component analysis. These types of models can be used for solving the source separation problem in which the latent variables should have a meaningful interpretation and represent the actual sources generating data. Source separation methods is the main focus of this work. Bayesian statistical theory provides a principled way to learn latent variable models and therefore to solve the source separation problem. The first part of this work studies variational Bayesian methods and their application to different latent variable models. The properties of variational Bayesian methods are investigated both theoretically and experimentally using linear source separation models. A new nonlinear factor analysis model which restricts the generative mapping to the practically important case of post-nonlinear mixtures is presented. The variational Bayesian approach to learning nonlinear state-space models is studied as well. This method is applied to the practical problem of detecting changes in the dynamics of complex nonlinear processes. The main drawback of Bayesian methods is their high computational burden. This complicates their use for exploratory data analysis in which observed data regularities often suggest what kind of models could be tried. Therefore, the second part of this work proposes several faster source separation algorithms implemented in a common algorithmic framework. The proposed approaches separate the sources by analyzing their spectral contents, decoupling their dynamic models or by optimizing their prominent variance structures. These algorithms are applied to spatio-temporal datasets containing global climate measurements from a long period of time.reviewe

Modeling and Reconstruction of Mixed Functional and Molecular Patterns

Functional medical imaging promises powerful tools for the visualization and elucidation of important disease-causing biological processes in living tissue. Recent research aims to dissect the distribution or expression of multiple biomarkers associated with disease progression or response, where the signals often represent a composite of more than one distinct source independent of spatial resolution. Formulating the task as a blind source separation or composite signal factorization problem, we report here a statistically principled method for modeling and reconstruction of mixed functional or molecular patterns. The computational algorithm is based on a latent variable model whose parameters are estimated using clustered component analysis. We demonstrate the principle and performance of the approaches on the breast cancer data sets acquired by dynamic contrast-enhanced magnetic resonance imaging

Algorithms of causal inference for the analysis of effective connectivity among brain regions

In recent years, powerful general algorithms of causal inference have been developed. In particular, in the framework of Pearl’s causality, algorithms of inductive causation (IC and IC*) provide a procedure to determine which causal connections among nodes in a network can be inferred from empirical observations even in the presence of latent variables, indicating the limits of what can be learned without active manipulation of the system. These algorithms can in principle become important complements to established techniques such as Granger causality and Dynamic Causal Modeling (DCM) to analyze causal influences (effective connectivity) among brain regions. However, their application to dynamic processes has not been yet examined. Here we study how to apply these algorithms to time-varying signals such as electrophysiological or neuroimaging signals. We propose a new algorithm which combines the basic principles of the previous algorithms with Granger causality to obtain a representation of the causal relations suited to dynamic processes. Furthermore, we use graphical criteria to predict dynamic statistical dependencies between the signals from the causal structure. We show how some problems for causal inference from neural signals (e.g., measurement noise, hemodynamic responses, and time aggregation) can be understood in a general graphical approach. Focusing on the effect of spatial aggregation, we show that when causal inference is performed at a coarser scale than the one at which the neural sources interact, results strongly depend on the degree of integration of the neural sources aggregated in the signals, and thus characterize more the intra-areal properties than the interactions among regions. We finally discuss how the explicit consideration of latent processes contributes to understand Granger causality and DCM as well as to distinguish functional and effective connectivity