Blockchain for Genomics:A Systematic Literature Review

Human genomic data carry unique information about an individual and offer unprecedented opportunities for healthcare. The clinical interpretations derived from large genomic datasets can greatly improve healthcare and pave the way for personalized medicine. Sharing genomic datasets, however, pose major challenges, as genomic data is different from traditional medical data, indirectly revealing information about descendants and relatives of the data owner and carrying valid information even after the owner passes away. Therefore, stringent data ownership and control measures are required when dealing with genomic data. In order to provide secure and accountable infrastructure, blockchain technologies offer a promising alternative to traditional distributed systems. Indeed, the research on blockchain-based infrastructures tailored to genomics is on the rise. However, there is a lack of a comprehensive literature review that summarizes the current state-of-the-art methods in the applications of blockchain in genomics. In this paper, we systematically look at the existing work both commercial and academic, and discuss the major opportunities and challenges. Our study is driven by five research questions that we aim to answer in our review. We also present our projections of future research directions which we hope the researchers interested in the area can benefit from

Blockchain for Genomics:A Systematic Literature Review

Human genomic data carry unique information about an individual and offer unprecedented opportunities for healthcare. The clinical interpretations derived from large genomic datasets can greatly improve healthcare and pave the way for personalized medicine. Sharing genomic datasets, however, pose major challenges, as genomic data is different from traditional medical data, indirectly revealing information about descendants and relatives of the data owner and carrying valid information even after the owner passes away. Therefore, stringent data ownership and control measures are required when dealing with genomic data. In order to provide secure and accountable infrastructure, blockchain technologies offer a promising alternative to traditional distributed systems. Indeed, the research on blockchain-based infrastructures tailored to genomics is on the rise. However, there is a lack of a comprehensive literature review that summarizes the current state-of-the-art methods in the applications of blockchain in genomics. In this paper, we systematically look at the existing work both commercial and academic, and discuss the major opportunities and challenges. Our study is driven by five research questions that we aim to answer in our review. We also present our projections of future research directions which we hope the researchers interested in the area can benefit from

Analyzing the Prospects of Blockchain in Healthcare Industry

Deployment of a secured healthcare information is a major challenge in a web based environment. Ehealth services are subjected to same security threats as other services. The purpose of blockchain is to provide a structure and security to the organization data. Healthcare data deals with confidential information. The medical records can be well organized and empower their propagation in a secured manner through the usage of blockchain technology. The study throws light on providing security of health services through blockchain technology. The authors have analysed the various aspects of role of blockchain in healthcare through an extensive literature review. The application of blockchain in covid-19 has also been analysed and discussed in the study. Further application of blockchain in Indian healthcare has been highlighted in the paper. The study provides suggestions for strengthening the healthcare system by blending machine learning, artificial intelligence, big data, IoT with blockchain

Systematic review on ai-blockchain based e-healthcare records management systems

Electronic health records (EHRs) are digitally saved health records that provide information about a person's health. EHRs are generally shared among healthcare stakeholders, and thus are susceptible to power failures, data misuse, a lack of privacy, security, and an audit trail, among other problems. Blockchain, on the other hand, is a groundbreaking technology that provides a distributed and decentralized environment in which nodes in a list of networks can connect to each other without the need for a central authority. It has the potential to overcome the limits of EHR management and create a more secure, decentralized, and safer environment for exchanging EHR data. Further, blockchain is a distributed ledger on which data can be stored and shared in a cryptographically secure, validated, and mutually agreed-upon manner across all mining nodes. The blockchain stores data with a high level of integrity and robustness, and it cannot be altered. When smart contracts are used to make decisions and conduct analytics with machine-learning algorithms, the results may be trusted and unquestioned. However, Blockchain is not always indestructible and suffers from scalability and complexity issues that might render it inefficient. Combining AI and blockchain technology can handled some of the drawbacks of these two technical ecosystems effectively. AI algorithms rely on data or information to learn, analyze, and reach conclusions. The performance of AI algorithms is enhanced through the data obtained from a data repository or a reliable, secure, trustworthy, and credible platform. Researchers have identified three categories of blockchain-based potential solutions for the management of electronic health records: conceptual, prototype, and implemented. The purpose of this research work is to conduct a Systematic Literature Review (SLR) to identify and assess research articles that were either conceptual or implemented to manage EHRs using blockchain technology. The study conducts a comprehensive evaluation of the literature on blockchain technology and enhanced health record management systems utilizing artificial intelligence technologies. The study examined 189 research papers collected from various publication categories. The in-depth analysis focuses on the privacy, security, accessibility, and scalability of publications. The SLR has illustrated that blockchain technology has the potential to deliver decentralization, security, and privacy that are frequently lacking in traditional EHRs. Additionally, the outcomes of the extensive analysis inform future researchers about the type of blockchain to use in their research. Additionally, methods used in healthcare are summarized per application area while their pros and cons are highlighted. Finally, the emphasized taxonomy combines blockchain and artificial intelligence, which enables us to analyze possible blockchain and artificial intelligence applications in health records management systems. The article ends with a discussion on open issues for research and future directions

Towards Secure and Intelligent Diagnosis: Deep Learning and Blockchain Technology for Computer-Aided Diagnosis Systems

Cancer is the second leading cause of death across the world after cardiovascular disease. The survival rate of patients with cancerous tissue can significantly decrease due to late-stage diagnosis. Nowadays, advancements of whole slide imaging scanners have resulted in a dramatic increase of patient data in the domain of digital pathology. Large-scale histopathology images need to be analyzed promptly for early cancer detection which is critical for improving patient's survival rate and treatment planning. Advances of medical image processing and deep learning methods have facilitated the extraction and analysis of high-level features from histopathological data that could assist in life-critical diagnosis and reduce the considerable healthcare cost associated with cancer. In clinical trials, due to the complexity and large variance of collected image data, developing computer-aided diagnosis systems to support quantitative medical image analysis is an area of active research. The first goal of this research is to automate the classification and segmentation process of cancerous regions in histopathology images of different cancer tissues by developing models using deep learning-based architectures. In this research, a framework with different modules is proposed, including (1) data pre-processing, (2) data augmentation, (3) feature extraction, and (4) deep learning architectures. Four validation studies were designed to conduct this research. (1) differentiating benign and malignant lesions in breast cancer (2) differentiating between immature leukemic blasts and normal cells in leukemia cancer (3) differentiating benign and malignant regions in lung cancer, and (4) differentiating benign and malignant regions in colorectal cancer. Training machine learning models, disease diagnosis, and treatment often requires collecting patients' medical data. Privacy and trusted authenticity concerns make data owners reluctant to share their personal and medical data. Motivated by the advantages of Blockchain technology in healthcare data sharing frameworks, the focus of the second part of this research is to integrate Blockchain technology in computer-aided diagnosis systems to address the problems of managing access control, authentication, provenance, and confidentiality of sensitive medical data. To do so, a hierarchical identity and attribute-based access control mechanism using smart contract and Ethereum Blockchain is proposed to securely process healthcare data without revealing sensitive information to an unauthorized party leveraging the trustworthiness of transactions in a collaborative healthcare environment. The proposed access control mechanism provides a solution to the challenges associated with centralized access control systems and ensures data transparency and traceability for secure data sharing, and data ownership