Clinical application of high throughput molecular screening techniques for pharmacogenomics.

Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples. Increasing demand for genetic information may necessitate the use of high throughput diagnostic methods as part of clinically validated testing. Here we provide a general overview of our current and near-future abilities to perform large-scale genetic testing in the clinical laboratory. First we review in detail molecular methods used for high throughput mutation detection, including techniques able to monitor thousands of genetic variants for a single patient or to genotype a single genetic variant for thousands of patients simultaneously. These methods are analyzed in the context of pharmacogenomic testing in the clinical laboratories, with a focus on tests that are currently validated as well as those that hold strong promise for widespread clinical application in the near future. We further discuss the unique economic and clinical challenges posed by pharmacogenomic markers. Our ability to detect genetic variants frequently outstrips our ability to accurately interpret them in a clinical context, carrying implications both for test development and introduction into patient management algorithms. These complexities must be taken into account prior to the introduction of any pharmacogenomic biomarker into routine clinical testing

Action plan for deriving dynamic RES-E policies

The core objective of this project is to facilitate a continuous and significant increase in the share of RESE with minimal costs to European citizen. To identify the most important strategies (e.g. Tradable Green Certificates, Feed-In Tariffs, Investment Subsidies, Emissions Trading, CO2-taxes) in a dynamic way the computer-based toolbox Green-X has been developed. Although within the scope of this project it has not been feasible to investigate all possible issues within this field, the cases analysed cover not only the needs and opportunities at the level of the national Member States, but also those at the level ofthe EU. However, the most important ones have been treated thoroughly. This report, which is the final outcome from the Green-X project (Contract No: ENG2-CT-2002- 00607), with funding from the European Commission, DG Research, provides recommendations on the way forward for the promotion of renewable energy for electricity generation in the EU. It is addressed primarily to energy policy maker, as well as to other people interested in renewable energy and energy policy

Extending Message Passing Interface Windows to Storage

This work presents an extension to MPI supporting the one-sided communication model and window allocations in storage. Our design transparently integrates with the current MPI implementations, enabling applications to target MPI windows in storage, memory or both simultaneously, without major modifications. Initial performance results demonstrate that the presented MPI window extension could potentially be helpful for a wide-range of use-cases and with low-overhead