182 research outputs found
Two isomorphism criteria for directed colimits
Using the general notions of finitely presentable and finitely generated
object introduced by Gabriel and Ulmer in 1971, we prove that, in any (locally
small) category, two sequences of finitely presentable objects and morphisms
(or two sequences of finitely generated objects and monomorphisms) have
isomorphic colimits (=direct limits) if, and only if, they are confluent. The
latter means that the two given sequences can be connected by a back-and-forth
chain of morphisms that is cofinal on each side, and commutes with the
sequences at each finite stage. In several concrete situations, analogous
isomorphism criteria are typically obtained by ad hoc arguments. The abstract
results given here can play the useful r\^ole of discerning the general from
the specific in situations of actual interest. We illustrate by applying them
to varieties of algebras, on the one hand, and to dimension groups---the
ordered of approximately finite-dimensional C*-algebras---on the other.
The first application encompasses such classical examples as Kurosh's
isomorphism criterion for countable torsion-free Abelian groups of finite rank.
The second application yields the Bratteli-Elliott Isomorphism Criterion for
dimension groups. Finally, we discuss Bratteli's original isomorphism criterion
for approximately finite-dimensional C*-algebras, and show that his result does
not follow from ours.Comment: 10 page
Quiver Structure of Heterotic Moduli
We analyse the vector bundle moduli arising from generic heterotic
compactifications from the point of view of quiver representations. Phenomena
such as stability walls, crossing between chambers of supersymmetry, splitting
of non-Abelian bundles and dynamic generation of D-terms are succinctly encoded
into finite quivers. By studying the Poincar\'e polynomial of the quiver moduli
space using the Reineke formula, we can learn about such useful concepts as
Donaldson-Thomas invariants, instanton transitions and supersymmetry breaking.Comment: 38 pages, 5 figures, 1 tabl
Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society
Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud
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KEYWORDS: Emergence of Life and Human Consciousness;\ud
Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud
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