27,080 research outputs found
A Survey on Soft Subspace Clustering
Subspace clustering (SC) is a promising clustering technology to identify
clusters based on their associations with subspaces in high dimensional spaces.
SC can be classified into hard subspace clustering (HSC) and soft subspace
clustering (SSC). While HSC algorithms have been extensively studied and well
accepted by the scientific community, SSC algorithms are relatively new but
gaining more attention in recent years due to better adaptability. In the
paper, a comprehensive survey on existing SSC algorithms and the recent
development are presented. The SSC algorithms are classified systematically
into three main categories, namely, conventional SSC (CSSC), independent SSC
(ISSC) and extended SSC (XSSC). The characteristics of these algorithms are
highlighted and the potential future development of SSC is also discussed.Comment: This paper has been published in Information Sciences Journal in 201
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
- …