A power-efficient current generator with common mode signal autozero feedback for bioimpedance measurement applications

This paper describes the design of fully differential sine pulse-width-modulation (SPWM) wave current generator for bioimpedance measurement applications. The current generator has been designed in a 0.18-µm CMOS technology. Its analog front-end operates from ±1.65 V and has a current consumption of + + ( ×. ) where is the output current and is the operating frequency. It can provide outputs from to of SPWM current up to 98 kHz with a maximum voltage compliance of ±1.25 V. Using linear current feedback, the current generator has a designed transconductance of /. Feedback also enables cancellation of common mode signals and a high output impedance

Time Stamp – A Novel Time-to-Digital Demodulation Method for Bioimpedance Implant Applications

Bioimpedance analysis is a noninvasive and inexpensive technology used to investigate the electrical properties of biological tissues. The analysis requires demodulation to extract the real and imaginary parts of the impedance. Conventional systems use complex architectures such as I-Q demodulation. In this paper, a very simple alternative time-to-digital demodulation method or ‘time stamp’ is proposed. It employs only three comparators to identify or stamp in the time domain, the crossing points of the excitation signal, and the measured signal. In a CMOS proof of concept design, the accuracy of impedance magnitude and phase is 97.06% and 98.81% respectively over a bandwidth of 10 kHz to 500 kHz. The effect of fractional-N synthesis is analysed for the counter-based zero crossing phase detector obtaining a finer phase resolution (0.51˚ at 500 kHz) using a counter clock frequency ( fclk = 12.5 MHz). Because of its circuit simplicity and ease of transmitting the time stamps, the method is very suited to implantable devices requiring low area and power consumption

An Imaged-Based Method for Universal Performance Evaluation of Electrical Impedance Tomography Systems

This paper describes a simple and reproducible methodology for universal evaluation of the performance of electrical impedance tomography (EIT) systems using reconstructed images. Based on objective full referencing (FR), the method provides a visually distinguishable hot colormap and two new FR metrics, the global and the more specific region of interest, to address the issues where common electrical parameters are not directly related to the quality of EIT images. A passive 16 electrode EIT system using an application specific integrated circuit front-end was used to evaluate the proposed method. The measured results show, both visually and in terms of the proposed FR metrics, the impact on recorded EIT images with different design parameters and non-idealities. The paper also compares the image results of a passive electrode system with a matched single variable active electrode system and demonstrates the merit of an active electrode system for noise interference

Energy-Efficient PRBS Impedance Spectroscopy on a Digital Versatile Platform

partially_open6siThis research has been partially funded by the Italian Ministry of University and Research (MUR) through the program “Dipartimenti di Eccellenza” (2018-2022). The research has also received partial support from the Italian Ministry of University and Research (MUR) and the Eranet FLAG ERA initiative within CONVERGENCE project (CUP B84I16000030005) through the IUNET Consortium.This paper presents the digital design of a versatile and low-power broadband impedance spectroscopy (IS) system based on pseudo-random binary sequence (PRBS) excitation. The PRBS technique allows fast, and low-power estimation of the impedance spectrum over a wide bandwidth with adequate accuracy, proving to be a good candidate for portable medical devices, especially. This paper covers the low-power design of the firmware algorithms and implements them on a versatile and reconfigurable digital platform that can be easily adjusted to the specific application. It will analyze the digital platform with the aim of reducing power consumption while maintaining adequate accuracy of the estimated spectrum. The paper studies two main algorithms (time-domain and frequency-domain) used for PRBS-based IS and implements both of them on the ultra-low-power GAP-8 digital platform. They are compared in terms of accuracy, measurement time, and power budget, while general design trade-offs are drawn out. The time-domain algorithm demonstrated the best accuracy while the frequency-domain one contributes more to save power and energy. However, analysis of the energy-per-error FOM revealed that the time-domain algorithm outperforms the frequency-domain algorithm offering better accuracy for the same energy consumption. Numerical methods and microprocessor resources are exploited to optimize the implementation of both algorithms achieving 27 ms in processing time, power consumption as low as 1.4 mW and a minimum energy consumption per measurement of 0.5 mJ, for a dense impedance spectrum estimation of 214 points.embargoed_20210525Luciani G.; Crescentini M.; Romani A.; Chiani M.; Benini L.; Tartagni M.Luciani G.; Crescentini M.; Romani A.; Chiani M.; Benini L.; Tartagni M

Self-diagnosis implantable optrode for optogenetic stimulation

PhD ThesisAs a cell type-specific neuromodulation method, optogenetic technique holds remarkable potential for the realisation of advanced neuroprostheses. By genetically expressing light-sensitive proteins such as channelrhodopsin-2 (ChR2) in cell membranes, targeted neurons could be controlled by blue light. This new neuromodulation technique could then be applied into extensive brain networks and be utilised to provide effective therapies for neurological disorders. However, the development of novel optogenetic implants is still a key challenge in the field. The major requirements include small device dimensions, suitable spatial resolution, high safety, and strong controllability. In particular, appropriate implantable electronics are expected to be built into the device, accomplishing a new-generation intelligent optogenetic implant. To date, different microfabrication techniques, such as wave-guided laser/light-emitting diode (LED) structure and μLED-on-optrode structure, have been widely explored to create and miniaturise optogenetic implants. However, although these existing devices meet the requirements to some extent, there is still considerable room for improvement. In this thesis, a Complementary Metal-Oxide-Semiconductor (CMOS)-driven μLED approach is proposed to develop an advanced implantable optrode. This design is based on the μLED-on-optrode structure, where Gallium Nitride (GaN) μLEDs can be directly bonded to provide precise local light delivery and multi-layer stimulation. Moreover, an in-built diagnostic sensing circuitry is designed to monitor optrode integrity and degradation. This self-diagnosis function greatly improves system reliability and safety. Furthermore, in-situ temperature sensors are incorporated to monitor the local thermal effects of light emitters. This ensures both circuitry stability and tissue health. More importantly, external neural recording circuitry is integrated into the implant, which could observe local neural signals in the vicinity of the stimulation sites. Therefore, a CMOS-based multi-sensor optogenetic implant is achieved, and this closed-loop neural interface is capable of performing multichannel optical neural stimulation and electrical neural recording simultaneously. This optrode is expected to represent a promising neural interface for broad neuroprosthesis applications