Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia

Hypofunction of N-methyl-D-aspartate (NMDA) receptor-mediated signal transduction has been implicated in the pathophysiology of schizophrenia. Post-synaptic density protein 95 (PSD95) plays a critical role in regulating the trafficking and activity of the NMDA receptor and altered expression of the PSD95 has been detected in the post-mortem brain of patients with schizophrenia. The study aimed to examine whether the DLG4 gene that encodes the PSD95 may confer genetic susceptibility to schizophrenia. We re-sequenced the core promoter, all the exons, and 3′ untranslated regions (UTR) of the DLG4 gene in 588 Taiwanese schizophrenic patients and conducted an association study with 539 non-psychotic subjects. We did not detect any rare mutations at the protein-coding sequences of the DLG4 gene associated with schizophrenia. Nevertheless, we identified four polymorphic markers at the core promoter and 5′ UTR and one single nucleotide polymorphism (SNP) at the 3′UTR of the DLG4 gene in this sample. Genetic analysis showed an association of a haplotype (C–D) derived from 2 polymorphic markers at the core promoter (odds ratio = 1.26, 95% confidence interval = 1.06–1.51, p = 0.01), and a borderline association of the T allele of the rs13331 at 3′UTR with schizophrenia (odds ratio = 1.19, 95% confidence interval = 0.99–1.43, p = 0.06). Further reporter gene assay showed that the C-D-C-C and the T allele of the rs13331 had significant lower activity than their counter parts. Our data indicate that the expression of the DLG4 gene is subject to regulation by the polymorphic markers at the core promoter region, 5′ and 3′UTR of the gene, and is associated with the susceptibility of schizophrenia

A new heuristic for broadcasting in clusters of clusters

International audienceThis paper deals with the problem of broadcasting for clus- ter of clusters. The construction of partial minimum spanning trees being NP-complete, several heuristic algorithms have been already formulated. Many of these heuristics (like the heuristic of Kruskal) use the shortest path to connect the components of the tree. They are not relevant in case of forwarding or overlapping communication during a step of the algorithm. In this paper, we study a new heuristic for the minimum broadcasting tree and we evaluate it through simulations with different communication parameters and also through real experimentation over the Grid'5000 testbed

Migration of Multi-Tier Applications to Infrastructure-As-A-Service Clouds: An Investigation Using Kernel-Based Virtual Machines

To investigate challenges of multi -tier application migration to Infrastructure -as-a- Service (IaaS) clouds we performed an experimental investigation by deploying a processor bound and input -output bound variant of the RUSLE2 erosion model to an IaaS base d private cloud. Scaling the applications to achieve optimal system throughput is complex and involves much more than simply increasing the number of allotted virtual machines (VMs). While scaling the application variants a series of bottlenecks were encountered unique to an application\u27s processing, I/O, and memory requirements, herein referred to as an application\u27s profile. To investigate the impact of provisioning variation for hosting multi -tier applications we tested four schemes of VM deployments across the physical nodes of our cloud. Performance degradation was more pronounced when multiple I/O or CPU resource intensive application components were co -located on the same physical hardware. We investigated the virtualization overhead incurred using Kernel -based virtual machines (KVM) by deploying our application variants to both physical and virtual machines. Overhead varied based on the unique characteristics of each application\u27s profile. We observed ~112% overhead for the input/output bound application and just ~ 10 % overhead for the processor bound application. Understanding an application\u27s profile was found to be important for optimal IaaS -based cloud migration and scaling

Parallel fast fourier transform in SPMD style of cilk

Copyright © 2019 Inderscience Enterprises Ltd. In this paper, we propose a parallel one-dimensional non-recursive fast Fourier transform (FFT) program based on conventional Cooley-Tukey’s algorithm written in C using Cilk in single program multiple data (SPMD) style. As a highly compact designed code, this code is compared with a highly tuned parallel recursive fast Fourier transform (FFT) using Cilk, which is included in Cilk package of version 5.4.6. Both algorithms are executed on multicore servers, and experimental results show that the performance of the SPMD style of Cilk fast Fourier transform (FFT) parallel code is highly competitive and promising

Applying wavelet analysis to the X-ray light curves of active galactic nuclei and quasi-periodic eruptions

In this work, we examine the application of the wavelet transform to the X-ray timing analyses of active galactic nuclei (AGN) and quasi-periodic eruption sources (QPEs). Several scenarios are simulated to test the effectiveness of the wavelet analysis to stationary and non-stationary data. We find that the power spectral density (PSD) slope and the nature of the periodic signal can influence the ability to identify important features in the wavelet power spectrum. In general, weak and transient features can be discerned, which make the wavelet spectrum an important tool in examining AGN light curves. We carried out a wavelet analysis to four unique objects: Ark 120, IRAS 13224-3809, RE J1034+396, and the QPE GSN 069. The well-known quasi-periodic oscillation (QPO) in RE J1034+396 is significantly detected in the wavelet power spectrum. In IRAS 13224-3809, significant transient features appear during a flare at frequencies coincident with previously detected reverberation signals. Finally, the wavelet power spectrum of the QPE GSN 069 significantly reveals four persistent signals that exhibit a 3:2 ratio in oscillation frequencies, consistent with high-frequency QPOs in stellar mass X-ray binaries, but we cannot rule out the possibility this is an artefact of the calculation.Comment: 14 pages, 14 figures, Accepted for publication to MNRA

RESILIENCE AND RESISTANCE, A NATO MODEL FOR TAIWAN

Reissued 14 Feb. 2022 to update text on page 48.Nowhere in the world exemplifies Great Power Competition as strongly as simmering conflict over Taiwan. Spanning over seven decades, the Republic of China (Taiwan) and the People’s Republic of China (PRC) have sparred over the status of the island. Despite the Chinese Communist Party’s (CCP) protests, over the last three presidential administrations, the U.S. has strengthened its support for Taiwan’s vibrant democracy. In addition to the U.S., the European Union and several countries in the Asia-Pacific region also strongly support an autonomous Taiwan. In response to what the CCP sees as foreign meddling in Chinese domestic affairs, the PRC has increased its hostilities against Taiwan while also attempting to reduce international support for the island's democracy. How can Taiwan maintain its autonomy despite the ever-increasing pressure from the much stronger PRC? Through analysis of Arreguin-Toft’s “How the Weak Wins Wars,” Fiala’s “Resistance Operating Concept,” NATO’s “Comprehensive Defense Handbook,” and Taiwan’s recent efforts to create an all-out defense, this thesis offers findings and recommendations based on employing irregular warfare to increase the population's resiliency and deter or repel a PRC invasion.Chief Warrant Officer Three, United States ArmyMajor, United States ArmyApproved for public release. Distribution is unlimited

Cross-language Transfer of Reading Ability: Evidence from Taiwanese Ninth-grade Adolescents

The influence of reading ability on cross-language transfer in Mandarin-speaking ninth graders was explored. Each participant's native language (L1-Mandarin Chinese) and second language (L2-English) were assessed. Although the relationship between L1 and L2 reading ability has been discussed in many previous studies, few studies have examined this relationship among L2 readers whose L1 is sharply different from their L2, who are at the junior-high-school age range, and who are learning English in a setting where English is not used in daily communication (e.g., English as a foreign language). To investigate the role of L1 reading competence in the language reading ability transfer, a reformed public examination, called the Basic Competency Test (BCT), was applied in this study. The 30,000 Taiwanese ninth grade participants, randomly selected from the pool of the national examination involved in a consecutive six-year period, were considered as a whole and then disaggregated into six groups based on the year they took the BCT. A preliminary analysis was about reliability coefficients of twelve examinations (six in Mandarin Chinese reading, and six in English reading) used in the present study. Scores from both Mandarin Chinese and English reading comprehension tests were subjected to descriptive, correlational, and regressional analyses. Both correlation and regression analyses revealed congruent results that provided support for the positive influence of Mandarin Chinese reading competence on English reading ability, that is, L2 reading ability is dependent on L1 reading competence. The finding supported the Linguistic Interdependence Hypothesis. In addition, participants' gender and school district also played statistically significant roles to affect the cross-language transfer of reading ability, whereas the length of time in English exposure had no statistically significant effect on the language reading ability transfer. Thus, cross-language transfer in reading ability was influenced by learners' L1 reading competence, gender, and school district. This suggested educational policy makers in Taiwan that boost native-Chinese speaking students' Mandarin knowledge help support the development of English reading ability. Apparently, if students' L1 reading abilities can be built up more soundly, their L2 reading ability should be easier to acquire

Using wavelet analysis to study AGN x-ray variability

1 online resource (ix, 97 pages) : colour illustrations, charts (some colour), graphs (some colour)Includes abstract.Includes bibliographical references (pages 89-97).In this work, we examine the application of the wavelet transform to the X-ray timing analyses of active galactic nuclei (AGN) and quasi-periodic eruption sources (QPEs). We find that the power spectral density (PSD) slope and the nature of the periodic signal can influence the ability to identify important features in the wavelet power spectrum. Several scenarios are simulated to test the effectiveness of the wavelet analysis to stationary and non-stationary data. We carried out a wavelet analysis to five unique objects: Ark 120, IRAS 13224-3809, RE J1034+396, the QPE GSN 069, and the eclipsing NGC 6814. The well-known quasi-periodic oscillation (QPO) in RE J1034+396 is significantly detected in the wavelet power spectrum. In IRAS 13224-3809, significant transient features appear during a flare at frequencies coincident with previously detected reverberation signals. The wavelet power spectrum of the QPE GSN 069 significantly reveals four persistent signals