No X-Ray Excess from the HESS J1741-302 Region except a New Intermediate Polar Candidate

With the Suzaku satellite, we observed an unidentified TeV gamma-ray source HESS J1741$-$302 and its surroundings. No diffuse or point-like X-ray sources are detected from the bright southern emission peak of HESS J1741$-$302. From its neighborhood, we found a new intermediate polar candidate at the position of (\alpha, \delta)_{\rm J2000.0} = (\timeform{17h40m35.6s}, \timeform{-30D14m16s}), which is designated as Suzaku J174035.6$-$301416. The spectrum of Suzaku J174035.6$-$301416 exhibits emission lines at the energy of 6.4, 6.7 and 7.0 keV, which can be assigned as the K$\alpha$ lines from neutral, He-like and H-like iron, respectively. A coherent pulsation is found at a period of 432.1 $\pm$ 0.1 s. The pulse profile is quasi-sinusoidal in the hard X-ray band (4$-$8 keV), but is more complicated in the soft X-ray band (1$-$3 keV). The moderate period of pulsation, the energy flux, and the presence of the iron K$\alpha$ lines indicate that Suzaku J174035.6$-$301416 is likely an intermediate polar, a subclass of magnetized white dwarf binaries (cataclysmic variables). Based on these discoveries, we give some implications on the origin of GCDX and brief comments on HESS J1741$-$302 and PSR B1737$-$30.Comment: Accepted by PAS

CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis

The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules. Since the acrosome reaction resembles Ca(2+)-regulated exocytosis in neurons, we investigated whether cognate neuronal binding partners of the multi-PDZ domain protein MUPP1, which recruits molecules that control the initial tethering and/or docking between the acrosomal vesicle and the plasma membrane, are also expressed in spermatozoa, and whether they contribute to the regulation of acrosomal secretion. We observed that CaMKIIalpha colocalizes with MUPP1 in the acrosomal region of epididymal spermatozoa where the kinase selectively binds to a region encompassing PDZ domains 10-11 of MUPP1. Furthermore, we found that pre-treating mouse spermatozoa with a CaMKII inhibitor that directly blocks the catalytic region of the kinase, as well as a competitive displacement of CaMKIIalpha from PDZ domains 10-11, led to a significant increase in spontaneous acrosomal exocytosis. Since Ca(2+)-calmodulin releases CaMKIIalpha from the PDZ scaffolding protein, MUPP1 represents a central signaling platform to dynamically regulate the assembly and disassembly of binding partners pertinent to acrosomal secretion, thereby precisely adjusting an increase in Ca(2+) to synchronized fusion pore formation

(Biphenyl-2-yl)bromidobis(2-methyltetrahydrofuran-[kappa]O)magnesium(II)

In the title Grignard reagent, [MgBr(C12H9)(C5H10O)2], the Mg centre adopts a distorted tetrahedral MgCO2Br arrangement. The dihedral angle between the two aromatic rings of the biphenyl residue is 44.00 (14)°. Each molecule incorporates one R- and one S-configured 2-methyltetrahydrofuran molecule. Key indicators: single-crystal X-ray study; T = 173 K; mean σ(C–C) = 0.007 Å; R factor = 0.045; wR factor = 0.108; data-to-parameter ratio = 17.4

The Formation and Fragmentation of Disks around Primordial Protostars

The very first stars to form in the Universe heralded an end to the cosmic dark ages and introduced new physical processes that shaped early cosmic evolution. Until now, it was thought that these stars lived short, solitary lives, with only one extremely massive star, or possibly a very wide binary system, forming in each dark matter minihalo. Here we describe numerical simulations that show that these stars were, to the contrary, often members of tight multiple systems. Our results show that the disks that formed around the first young stars were unstable to gravitational fragmentation, possibly producing small binary and higher-order systems that had separations as small as the distance between the Earth and the Sun.Comment: This manuscript has been accepted for publication in Science. This version has not undergone final editing. Please refer to the complete version of record at http://www.sciencemag.org

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions