Data assimilation for Mars: an overview of results from the Mars Global Surveyor period, proposals for future plans and requirements for open access to assimilation output

Abstract not available. From the introduction: 'The Thermal Emission Spectrometer (TES) aboard Mars Global Surveyor (MGS) has produced an extensive atmospheric data set, both during the initial aerobraking hiatus and later from the scientific mapping phase of the mission which lasted almost three complete Martian seasonal cycles. Thermal profiles for the atmosphere below about 40 km, and total dust and water ice opacities, have been retrieved from TES spectra (Conrath et al., 2000, Smith et al., 2000)...'

Perspectives on financial incentives to health service providers for increasing breast feeding and smoking quit rates during pregnancy: a mixed methods study

Objective: To explore the acceptability, mechanisms and consequences of provider incentives for smoking cessation and breast feeding as part of the Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS) study. Design: Cross-sectional survey and qualitative interviews. Setting: Scotland and North West England. Participants: Early years professionals: 497 survey respondents included 156 doctors; 197 health visitors/maternity staff; 144 other health staff. Qualitative interviews or focus groups were conducted with 68 pregnant/postnatal women/family members; 32 service providers; 22 experts/decision-makers; 63 conference attendees. Methods: Early years professionals were surveyed via email about the acceptability of payments to local health services for reaching smoking cessation in pregnancy and breastfeeding targets. Agreement was measured on a 5-point scale using multivariable ordered logit models. A framework approach was used to analyse free-text survey responses and qualitative data. Results: Health professional net agreement for provider incentives for smoking cessation targets was 52.9% (263/497); net disagreement was 28.6% (142/497). Health visitors/maternity staff were more likely than doctors to agree: OR 2.35 (95% CI 1.51 to 3.64; p<0.001). Net agreement for provider incentives for breastfeeding targets was 44.1% (219/497) and net disagreement was 38.6% (192/497). Agreement was more likely for women (compared with men): OR 1.81 (1.09 to 3.00; p=0.023) and health visitors/maternity staff (compared with doctors): OR 2.54 (95% CI 1.65 to 3.91; p<0.001). Key emergent themes were 'moral tensions around acceptability', 'need for incentives', 'goals', 'collective or divisive action' and 'monitoring and proof'. While provider incentives can focus action and resources, tensions around the impact on relationships raised concerns. Pressure, burden of proof, gaming, box-ticking bureaucracies and health inequalities were counterbalances to potential benefits. Conclusions: Provider incentives are favoured by non-medical staff. Solutions which increase trust and collaboration towards shared goals, without negatively impacting on relationships or increasing bureaucracy are required

Clark W. Beasley (1942–2012)

Mcinnes, Sandra J. (2013): Clark W. Beasley (1942-2012). Zootaxa 3652 (4): 497-500, DOI: http://dx.doi.org/10.11646/zootaxa.3652.4.

Regional index of sustainable economic well-being development project: final report

This report presents results from a development project carried out by nef (the new economics foundation) on behalf of emda (the East Midlands Development Agency) and Natural England, to improve the methodologies used in the calculation of the R-ISEW (Regional Index of Sustainable Economic Well-Being)

Everything counts in small amounts

This paper describes an encoding tool which utilises the "data is code" principle of symbolic expressions available in Lisp-like languages to allow the scripting of tightly packed, cross-platform network protocols. This dynamic approach provides specific flexibility when working on embedded systems as it reduces the amount of cross compilation and deploy cycles that occur following more traditional development approaches. In addition, the separation of how the data is encoded from the compiled application facilitates a concept known as extensibility of the network protocol without requiring special handling

The Western Irish Namurian Basin reassessed

Current basin models for the Western Irish Namurian Basin (WINB) envisage an elongate trough along the line of the present-day Shannon Estuary that was infilled with clastic sediments derived from a hinterland that lay to the W or NW. This paper argues for an alternative basin configuration with source areas to the SW supplying sediment to a basin where deepest water conditions were in northern County Clare. Rapid subsidence along the present-day Shannon Estuary ponded sediment in this area throughout the early Namurian and, only with the rapid increase of sedimentation rates within the mid-Namurian (Kinderscoutian Stage), were substantial amounts of sediment able to prograde to the NE of the basin. This alternative model better explains the overwhelming predominance of NE-directed palaeocurrents in the Namurian infill, but requires fundamental revisions to most aspects of current depositional models. Deep-water black shales (Clare Shale Formation) initially accumulated throughout the region and were progressively downlapped by an unconfined turbidite system (Ross Formation) prograding to the NE. This in turn was succeeded by an unstable, siltstone-dominated slope system (Gull Island Formation) characterized by large-scale soft-sediment deformation, which also prograded to the NE. In the northern-most basin outcrops, in northern County Clare, this early phase of basin infill was developed as a condensed succession of radiolarian-rich black shales, minor turbiditic sandstones and undisturbed siltstones. The new basin model envisages the northern exposures of County Clare to be a distal, basin floor succession whereas the traditional model considers it a relatively shallow, winnowed, basin margin succession. Later stages of basin infill consist of a series of deltaic cycles that culminate in major, erosive-based sandstone bodies (e.g. Tullig Sandstone) interpreted either as axial, deltaic feeder channels or incised valley fills genetically unrelated to the underlying deltaic facies. Within the context of the new basin model the former alternative is most likely and estimated channel depths within the Tullig Sandstone indicate that the basal erosive surface could have been generated by intrinsic fluvial scour without recourse to base-level fall. The northerly flowing Tullig channels pass down-dip into isolated channel sandbodies interbedded with wave-dominated strata that suggest the deltas of the WINB were considerably more wave-influenced than hitherto proposed. The retreat of the Tullig delta during sea-level rise saw the rapid southerly retrogradation of parasequences, as may be expected if the basin margin lay to the SW of the present-day outcrops

MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1.

The mechanism of cisplatin resistance in ovarian cancer is not clearly understood. In the present investigation, we found that the expression levels of miR-497 were reduced in chemotherapy-resistant ovarian cancer cells and tumor tissues due to hypermethylation of miR-497 promoter. Low miR-497 expression levels were associated with chemo-resistant phonotype of ovarian cancer. By analyzing the expression levels of miR-497, mTOR and p70S6K1 in a clinical gene-expression array dataset, we found that mTOR and p70S6K1, two proteins correlated to chemotherapy-resistance in multiple types of human cancers, were inversely correlated with miR-497 levels in ovarian cancer tissues. By using an orthotopic ovarian tumor model and a Tet-On inducible miR-497 expression system, our results demonstrated that overexpression of miR-497 sensitizes the resistant ovarian tumor to cisplatin treatment. Therefore, we suggest that miR-497 might be used as a therapeutic supplement to increase ovarian cancer treatment response to cisplatin

Chords, tangents and the Leibniz notation

In this article I continue my quest for “understanding the calculus” 1,2 by looking at a practical approach to the notion of a tangent and linking it to the Leibniz notation dy/dx in a meaningful way. The latter is a bête noire for students: it looks like a quotient, it acts like a quotient, yet the seeds of a classic psychological conflict are sown in their minds when they are told it must not be thought of as a quotient. I shall discuss how this conflict may be resolved so that the chain law allows cancellation