SOURCES OF CHANGE IN STATE-LEVEL AGRICULTURAL PRODUCTION IN MEXICO: IMPLICATIONS FROM THE PESO CRISIS OF 1994-1995

Production Economics,

Oscillatory EEG activity during REM sleep in elderly people predicts subsequent dream recall after awakenings

Several findings underlined that the electrophysiological (EEG) background of the last segment of sleep before awakenings may predict the presence/absence of dream recall (DR) in young subjects. However, little is known about the EEG correlates of DR in elderly people. Only an investigation found differences between recall and non-recall conditions during NREM sleep EEG in older adults, while—surprisingly—no EEG predictor of DR was found for what concerns REMsleep. Considering REMsleep as a privileged scenario to produce mental sleep activity related to cognitive processes, our study aimed to investigate whether specific EEG topography and frequency changes during REM sleep in elderly people may predict a subsequent recall of mental sleep activity. Twenty-one healthy older volunteers (mean age 69.2 ± 6.07 SD) and 20 young adults (mean age 23.4 ± 2.76 SD) were recorded for one night from19 scalp derivations. Dreams were collected upon morning awakenings from REM sleep. EEG signals of the last 5min were analyzed by the Better OSCillation algorithm to detect the peaks of oscillatory activity in both groups. Statistical comparisons revealed that older as well as young individuals recall their dream experience when the last segment of REM sleep is characterized by frontal theta oscillations. No Recall (Recall vs. Non-Recall) × Age (Young vs. Older) interaction was found. This result replicated the previous evidence in healthy young subjects, as shown in within- and between-subjects design. The findings are completely original for older individuals, demonstrating that theta oscillations are crucial for the retrieval of dreaming also in this population. Furthermore, our results did not confirm a greater presence of the theta activity in healthy aging. Conversely, we found a greater amount of rhythmic theta and alpha activity in young than older participants. It is worth noting that the theta oscillations detected are related to cognitive functioning. We emphasize the notion that the oscillatory theta activity should be distinguished from the non-rhythmic theta activity identified in relation to other phenomena such as (a) sleepiness and hypoarousal conditions during the waking state and (b) cortical slowing, considered as an EEG alteration in clinical samples

A General Large Neighborhood Search Framework for Solving Integer Programs

This paper studies how to design abstractions of large-scale combinatorial optimization problems that can leverage existing state-of-the-art solvers in general purpose ways, and that are amenable to data-driven design. The goal is to arrive at new approaches that can reliably outperform existing solvers in wall-clock time. We focus on solving integer programs, and ground our approach in the large neighborhood search (LNS) paradigm, which iteratively chooses a subset of variables to optimize while leaving the remainder fixed. The appeal of LNS is that it can easily use any existing solver as a subroutine, and thus can inherit the benefits of carefully engineered heuristic approaches and their software implementations. We also show that one can learn a good neighborhood selector from training data. Through an extensive empirical validation, we demonstrate that our LNS framework can significantly outperform, in wall-clock time, compared to state-of-the-art commercial solvers such as Gurobi

Las constituciones de las Américas: sus procesos de enmienda

Robert S. Barker (biografía): Profesor norteamericano de derecho de la Duquesne University School of Law, de la que también es egresado. Obtuvo una maestría en historia americana en la Universidad de Duquesne. Fue becario de la Fulbright. Fue editor de la Duquesne University Law Review. Antes de ser profesor a tiempo completo, trabajó como abogado tanto al servicio de la comunidad (Neighborhood Legal Services) como asociado a la firma privada de abogados Rose, Schmidt and Dixon. También fue oficial del Programa de Ciudades Modelos de la Ciudad de Pittsburgh, se desempeñó como asistente de profesor y del decano en la Duquesne University School of Law y como consejero legal del Aeropuerto Internacional de Pittsburgh. Asimismo, fue presidente y vicepresidente del Comité en materia de derecho de aeropuertos de la Asociación Americana de Abogados. Por 12 años se desempeñó como presidente del Comité de Derecho Constitucional de la Asociación Inter-Americana de Abogados. Ha sido profesor invitado de derecho constitucional en la Universidad de Buenos Aires. Entre sus libros se encuentran La Constitución de los Estados Unidos y su dinámica actual, Constitutional Adjudication: The Costa Rican Experience y El precedente y su significado en el derecho constitucional de los Estados Unidos. En el 2001 fue reconocido como “Profesor Distinguido de Derecho” de la Universidad de Duquesne, y en el 2014 la Universidad Nacional de Cajamarca (Perú) le otorgó el Doctorado Honoris Causa.Este es un texto sobre derecho constitucional, específicamente sobre los mecanismos que han establecido los estados americanos para la reforma de sus constituciones. Para el autor, no existe un sistema único de reforma para todos los países, sino que el mecanismo de modificación constitucional depende de la propia tradición y cultura jurídica, así como de los recursos y necesidades que presente cada sociedad política nacional. Sin embargo, entiende que en dicho ámbito debe haber un equilibrio entre la permanencia y el cambio, de suerte que se mantengan los principios que empujan a las sociedades a asumir un estado de derecho pleno, al tiempo que se dé la flexibilidad suficiente para mejorar el funcionamiento de las instituciones públicas y para adaptarlas a los nuevos desafíos que van surgiendo en el tiempo. En tal virtud, siguiendo la opinión del estadista norteamericano James Madison, el autor estima que no debe haber una “facilidad extrema” para las reformas constitucionales, pero tampoco una “exagerada dificultad” que perpetúe “sus defectos manifiestos”

Diabetes Mellitus and Reprogrammed Glucose Metabolism in Pancreatic Cancer: Features for Clinical Translation

The reprogrammed metabolism of cancer cells underlies the shift of glucose energetics from the highly efficient oxidative phosphorylation to the less efficient aerobic glycolysis, the Warburg effect. This phenomenon, with the activation of the glutamine pathway, advantage survival and proliferation of pancreatic ductal adenocarcinoma (PDAC) cells, which live in an adverse hypoxic and nutrient restricted microenvironment. In PDAC, glucose metabolic alterations occur also at the whole organism, diabetes mellitus (DM) being diagnosed in approximately 60% to 80% of patients. The association beteen PDAC and DM is a dual face phenomenon, DM being both a risk factor for and a consequence of this tumor type. Data from epidemiology indicate that longstanding DM increases PDAC risk 1.5 to 2.0 fold, probably because of the pro-proliferative effects of hyperinsulinemia. By contrast early onset DM, i.e. diabetes diagnosed no more than two years prior to cancer diagnosis, is considered a consequence of PDAC. Secondary DM is due to complex interactions between tumor cells, tumor microenvironment and pancreatic endocrine cells. In this scenario the role of the inflammatory S100A8 calcium binding protein, matrix metalloproteinases, Vanin1 or amylin has been experimentally demonstrated. However, the efforts made to translate in the clinical practice any individual new poteantial biomarker failed, because none reached enough sensitivity and specificity to be considered a reliable biomarker to diagnose PDAC even in high risk subjects as those with new onset DM. Therefore the identification and clinical validation of new biomarkers remains a challenge for future studies

Face Detection on Embedded Systems

Over recent years automated face detection and recognition (FDR) have gained significant attention from the commercial and research sectors. This paper presents an embedded face detection solution aimed at addressing the real-time image processing requirements within a wide range of applications. As face detection is a computationally intensive task, an embedded solution would give rise to opportunities for discrete economical devices that could be applied and integrated into a vast majority of applications. This work focuses on the use of FPGAs as the embedded prototyping technology where the thread of execution is carried out on an embedded soft-core processor. Custom instructions have been utilized as a means of applying software/hardware partitioning through which the computational bottlenecks are moved to hardware. A speedup by a factor of 110 was achieved from employing custom instructions and software optimizations

Estimates of the Aggregate Quarterly Capital Stock for the Post- War U.S. Economy

We construct quarterly aggregate gross and net capital stock series for the post-war U.S. economy using annual capital stock, capital depreciation, and capital discard figures along with quarterly investment series. We construct nominal and real measures of all three categories in the aggregate capital stock: consumer durable goods, producer durable goods, and business structures. In constructing the nominal series we take into account the changes in capital goods’ prices. The series are constructed using four different methods. Using time- and frequency domain techniques, we compare the constructed series and characterize their short-run, business cycle, and long-run cyclical properties. We find that the constructed series exhibit very different cyclical and shock persistence dynamics. Practical implications are discussed.Capital Stock, Consumer Durable Goods, Producer Durable Goods, Business Structures, Capital Depreciation and Discard, Capital Goods Prices, Frequency Domain, Cyclical Behavior, Linear Interpolation, Numerical Iteration

Assessing the congruence of thermal niche estimations derived from distribution and physiological data. A test using diving beetles.

A basic aim of ecology is to understand the determinants of organismal distribution, the niche concept and species distribution models providing key frameworks to approach the problem. As temperature is one of the most important factors affecting species distribution, the estimation of thermal limits is crucially important for inferring range constraints. It is expectable that thermal physiology data derived from laboratory experiments and species' occurrences may express different aspects of the species' niche. However, there is no study systematically testing this prediction in a given taxonomic group while controlling by potential phylogenetic inertia. We estimate the thermal niches of twelve Palaearctic diving beetles species using physiological data derived from experimental analyses in order to examine the extent to which these coincided with those estimated from distribution models based on observed occurrences. We found that thermal niche estimates derived from both approaches lack general congruence, and these results were similar before and after controlling by phylogeny. The congruence between potential distributions obtained from the two different procedures was also explored, and we found again that the percentage of agreement were not very high (~60%). We confirm that both thermal niche estimates derived from geographical and physiological data are likely to misrepresent the true range of climatic variation that these diving beetles are able to tolerate, and so these procedures could be considered as incomplete but complementary estimations of an inaccessible reality