86,481 research outputs found
The role of learning on industrial simulation design and analysis
The capability of modeling real-world system operations has turned simulation into an indispensable problemsolving methodology for business system design and analysis. Today, simulation supports decisions ranging
from sourcing to operations to finance, starting at the strategic level and proceeding towards tactical and
operational levels of decision-making. In such a dynamic setting, the practice of simulation goes beyond
being a static problem-solving exercise and requires integration with learning. This article discusses the role
of learning in simulation design and analysis motivated by the needs of industrial problems and describes
how selected tools of statistical learning can be utilized for this purpose
Multiobjective strategies for New Product Development in the pharmaceutical industry
New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems
Multiobjective strategies for New Product Development in the pharmaceutical industry
New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems
Parameter estimation in softmax decision-making models with linear objective functions
With an eye towards human-centered automation, we contribute to the
development of a systematic means to infer features of human decision-making
from behavioral data. Motivated by the common use of softmax selection in
models of human decision-making, we study the maximum likelihood parameter
estimation problem for softmax decision-making models with linear objective
functions. We present conditions under which the likelihood function is convex.
These allow us to provide sufficient conditions for convergence of the
resulting maximum likelihood estimator and to construct its asymptotic
distribution. In the case of models with nonlinear objective functions, we show
how the estimator can be applied by linearizing about a nominal parameter
value. We apply the estimator to fit the stochastic UCL (Upper Credible Limit)
model of human decision-making to human subject data. We show statistically
significant differences in behavior across related, but distinct, tasks.Comment: In pres
Transfer Learning for Improving Model Predictions in Highly Configurable Software
Modern software systems are built to be used in dynamic environments using
configuration capabilities to adapt to changes and external uncertainties. In a
self-adaptation context, we are often interested in reasoning about the
performance of the systems under different configurations. Usually, we learn a
black-box model based on real measurements to predict the performance of the
system given a specific configuration. However, as modern systems become more
complex, there are many configuration parameters that may interact and we end
up learning an exponentially large configuration space. Naturally, this does
not scale when relying on real measurements in the actual changing environment.
We propose a different solution: Instead of taking the measurements from the
real system, we learn the model using samples from other sources, such as
simulators that approximate performance of the real system at low cost. We
define a cost model that transform the traditional view of model learning into
a multi-objective problem that not only takes into account model accuracy but
also measurements effort as well. We evaluate our cost-aware transfer learning
solution using real-world configurable software including (i) a robotic system,
(ii) 3 different stream processing applications, and (iii) a NoSQL database
system. The experimental results demonstrate that our approach can achieve (a)
a high prediction accuracy, as well as (b) a high model reliability.Comment: To be published in the proceedings of the 12th International
Symposium on Software Engineering for Adaptive and Self-Managing Systems
(SEAMS'17
Set-based design of mechanical systems with design robustness integrated
This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the design process. It also encourages flexibility in design through communication in terms of ranges instead of fixed point values and subsequent alternative solutions resulting from intersection of these ranges. These alternative solutions can then be refined and selected according to the designersâ preferences and clientsâ needs. This paper presents a model and tools for integrated flexible design that take into account the manufacturing variations as well as the design objectives for finding inherently robust solutions using QCSP transformation through interval analysis. In order to demonstrate the approach, an example of design of rigid flange coupling with a variable number of bolts and a choice of bolts from ISO M standard has been resolved and demonstrated
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Decision support for build-to-order supply chain management through multiobjective optimization
This paper aims to identify the gaps in decision-making support based on
multiobjective optimization for build-to-order supply chain management (BTOSCM).
To this end, it reviews the literature available on modelling build-to-order
supply chains (BTO-SC) with the focus on adopting multiobjective optimization
(MOO) techniques as a decision support tool. The literature has been classified based
on the nature of the decisions in different part of the supply chain, and the key
decision areas across a typical BTO-SC are discussed in detail. Available software
packages suitable for supporting decision making in BTO supply chains are also
identified and their related solutions are outlined. The gap between the modelling and
optimization techniques developed in the literature and the decision support needed in
practice are highlighted and future research directions to better exploit the decision
support capabilities of MOO are proposed
Decision support for build-to-order supply chain management through multiobjective optimization
This is the post-print version of the final paper published in International Journal of Production Economics. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2010 Elsevier B.V.This paper aims to identify the gaps in decision-making support based on multiobjective optimization (MOO) for build-to-order supply chain management (BTO-SCM). To this end, it reviews the literature available on modelling build-to-order supply chains (BTO-SC) with the focus on adopting MOO techniques as a decision support tool. The literature has been classified based on the nature of the decisions in different part of the supply chain, and the key decision areas across a typical BTO-SC are discussed in detail. Available software packages suitable for supporting decision making in BTO supply chains are also identified and their related solutions are outlined. The gap between the modelling and optimization techniques developed in the literature and the decision support needed in practice are highlighted. Future research directions to better exploit the decision support capabilities of MOO are proposed. These include: reformulation of the extant optimization models with a MOO perspective, development of decision supports for interfaces not involving manufacturers, development of scenarios around service-based objectives, development of efficient solution tools, considering the interests of each supply chain party as a separate objective to account for fair treatment of their requirements, and applying the existing methodologies on real-life data sets.Brunel Research Initiative and Enterprise Fund (BRIEF
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