Big deal - good deal? Or is there a better deal?

The purchase by library consortia of all journals published by one publisher - the so-called Big Deal - is bad for small publishers and for large libraries even if - in the short-term - good for large publishers and for small libraries. The publishing and library communities need to find alternative purchasing models which provide better deals for those disadvantaged by the prevalence of the Big Deal, while retaining the benefit of scale in negotiation and supply

ENDOSCOPIC TYPMPANOMASTOID EXPLORATION [FUNCTIONAL ENDOSCOPIC EAR SURGERY-FEES]

Tympano mastoidectomy is usually performed using operating microscope. This study reports a case series of tympanomastoidectomy which was performed using an endoscope.Endoscopic Tympanomastoidectomy for atticoantral type of CSOM is an excellent technique for complete removal of cholesteatoma especially from inaccessible areas of middle ear cleft including facial recess, sinustympani Transmeatal removal of disease from mastoid antrum and even tip cells is possible withendoscopes. Preservation of as much of normal mucosa of the middle ear cleft is possible with thistechnique, which promotes early reaeration of the mastoid cavity leading to better hearing outcome.Soft wall reconstruction has distinctive advantage of short additional time for reconstruction procedures, restoration of self cleaning EAC, early post operative epithelisation of tympanicmembrane and the EAC. Limitation of endoscopic technique: The endoscopic technique of tympanomastoidectomy with softwall reconstruction is not possible in cases with large mastoid cavity and in ears where a thin lateral rim of bony meatal wall (that can support soft wall) is retained, because of extensive disease.Like Functional Endoscopic sinus surgery (FESS) for nose, Endoscopes have changed thetreatment concept of atticoantral disease, with complete removal of the disease andpreservation of normal mucosa, that restores the normal physiology of middle ear cleft. Thishas led to the development of new concept of Functional Endoscopic Ear Surgery (FEES) foratticoantral type of CSOM.

The Empire of Enterprise: Scottish Business Networks in Asian Trade, 1793-1810

The rise of British rule in India in the late eighteenth century was accompanied by the emergence of extensive business networks based on London, Calcutta and Canton. These networks, which organised the private trade of British civilians and military personnel in India, linked the export and import economies of Bengal, Madras, Java, the Philippines, the Malay peninsula and southern China, and came to dominate much of the regional trade of the Indian Ocean, as well as its links to Europe. Many of those engaged in this activity were Scots, and the connections between them - based in part on kinship - provided the institutional setting for the remittance of private money from Asia to Europe. While the activities of the East India Company provided an important part of the setting for these activities, much of them also depended on private enterprise and non-official networks. As a result, the volume of capital remitted from Bengal to Britain during the 1790s and 1800s was much larger than has previously been estimated

Building a Thermometer

The purpose of this activity is to build an instrument that can be used to measure water temperature. Students construct a soda-bottle thermometer, which is similar to the thermometer used by GLOBE schools. Both are based on the principle that most substances expand and contract as their temperature changes. This experiment also demonstrates the principle of heat transfer. The intended outcome is that students will understand why and how a standard thermometer works. Educational levels: Middle school

(2S)-4-Methyl-2-(1-oxo-1H-2,3-dihydroisoindol- 2-yl)pentanoic acid.

The title compound, C14H17NO3, exhibits carboxylic acid group disorder about the C—CO2 axis, with site occupancies of 0.79 (5):0.21 (5). Molecules are linked by intermolecular O—H O Ciso, C—H O Ciso and C—H (arene) interactions (iso = isoindolinone)