931 research outputs found
Challenges of Big Data Analysis
Big Data bring new opportunities to modern society and challenges to data
scientists. On one hand, Big Data hold great promises for discovering subtle
population patterns and heterogeneities that are not possible with small-scale
data. On the other hand, the massive sample size and high dimensionality of Big
Data introduce unique computational and statistical challenges, including
scalability and storage bottleneck, noise accumulation, spurious correlation,
incidental endogeneity, and measurement errors. These challenges are
distinguished and require new computational and statistical paradigm. This
article give overviews on the salient features of Big Data and how these
features impact on paradigm change on statistical and computational methods as
well as computing architectures. We also provide various new perspectives on
the Big Data analysis and computation. In particular, we emphasis on the
viability of the sparsest solution in high-confidence set and point out that
exogeneous assumptions in most statistical methods for Big Data can not be
validated due to incidental endogeneity. They can lead to wrong statistical
inferences and consequently wrong scientific conclusions
Scientific Computing Meets Big Data Technology: An Astronomy Use Case
Scientific analyses commonly compose multiple single-process programs into a
dataflow. An end-to-end dataflow of single-process programs is known as a
many-task application. Typically, tools from the HPC software stack are used to
parallelize these analyses. In this work, we investigate an alternate approach
that uses Apache Spark -- a modern big data platform -- to parallelize
many-task applications. We present Kira, a flexible and distributed astronomy
image processing toolkit using Apache Spark. We then use the Kira toolkit to
implement a Source Extractor application for astronomy images, called Kira SE.
With Kira SE as the use case, we study the programming flexibility, dataflow
richness, scheduling capacity and performance of Apache Spark running on the
EC2 cloud. By exploiting data locality, Kira SE achieves a 2.5x speedup over an
equivalent C program when analyzing a 1TB dataset using 512 cores on the Amazon
EC2 cloud. Furthermore, we show that by leveraging software originally designed
for big data infrastructure, Kira SE achieves competitive performance to the C
implementation running on the NERSC Edison supercomputer. Our experience with
Kira indicates that emerging Big Data platforms such as Apache Spark are a
performant alternative for many-task scientific applications
Design and evaluation of a genomics variant analysis pipeline using GATK Spark tools
Scalable and efficient processing of genome sequence data, i.e. for variant
discovery, is key to the mainstream adoption of High Throughput technology for
disease prevention and for clinical use. Achieving scalability, however,
requires a significant effort to enable the parallel execution of the analysis
tools that make up the pipelines. This is facilitated by the new Spark versions
of the well-known GATK toolkit, which offer a black-box approach by
transparently exploiting the underlying Map Reduce architecture. In this paper
we report on our experience implementing a standard variant discovery pipeline
using GATK 4.0 with Docker-based deployment over a cluster. We provide a
preliminary performance analysis, comparing the processing times and cost to
those of the new Microsoft Genomics Services
- …