An ALS-Associated Mutation in the C-terminal alpha-helix of TDP-43 Uncouples Condensate Formation and Amyloid Assembly

Abstract

This data set includes native mass spectrometry and ion mobility mass spectrometry data collected on a Synapt G2 Si HDMS instrument (Waters Corporation at the University of Leeds, processed using MassLynx 4.1. Thioflavin T fluorescence data collected on a FLUOstar omega plate reader (BMG Labtech, Ortenburg, Germany). Nephelometry measurements collected on a Nephelostar plate reader (BMG Labtech, Ortenburg, Germany). SLAB simulations generated using the CALVADOS python package and the CALVADOS2 force field