Platelet-Rich Fibrin’s effect on wound healing after apicotomy

Abstract

Introduction: In modern dentistry, damaged tissue can be replaced using autologous tissue transplantation (such as autologous bone or skin) or biomaterials (substitute materials for bone or skin reconstruction). Among the biomaterials used in bone tissue engineering, Platelet-Rich Fibrin (PRF) has recently gained considerable attention. This study aims to demonstrate the superiority of PRF in the healing process following surgical interventions for the treatment of chronic periapical inflammatory processes. Case description: A diagnosis of periapical chronic periodontitis was made in two patients, aged 16 and 48, and a treatment plan was developed. Surgical intervention (apicotomy) was performed on both patients. Venous blood was drawn from the patients, placed in a PRF centrifuge, and a biological material was obtained. The platelet-rich fibrin was subsequently applied to the lesions. X-rays were obtained prior to the intervention, as well as one month and two months post-procedure. Discussion: Significant improvement in the condition of the alveolar bone, which had been destroyed during the pathological inflammatory process, was observed in both patients. Autologous platelet storage through PRF is an easy and cost-effective method for obtaining high concentrations of growth factors to promote tissue healing. Previous clinical experience confirms that PRF can be considered as biomaterial with therapeutic properties that accelerate physiological healing. Conclusion/clinical significance: Currently available clinical evidence suggests that the healing rate of surgical sites reinforced with PRF is two to three times higher than that of standard surgical sites. Key Words: PRF, apicotomy, periapical processes