Advanced nanosystem for target recognition and precise dual-mode imaging-guided photothermal therapy against triple-negative breast cancer

Abstract

Triple-negative breast cancer (TNBC) presents significant diagnostic and therapeutic challenges due to the lack of targeted treatments, rapid progression, high recurrence and metastasis rates, and overall poorer prognosis. Herein, the targeted theranostic platform of cysteine-modified gold nanodots-sulfhydrated luteinizing hormone releasing hormone (CGN-SLR) nanosystem was designed for target recognition and precise dual-mode imaging-guided photothermal therapy (PTT) against TNBC. On the one hand, the CGN-SLR nanosystem can serve as an ideal targeting fluorescent probe and computed tomography (CT) enhancer to facilitate the accurate diagnosis and surgical guidance of TNBC. On the other hand, the CGN-SLR nanosystem with great targeting and PTT ability can significantly inhibit the growth of TNBC, without causing harm to normal tissues and healthy organs. It provides an effective strategy for the diagnosis and treatment of TNBC through the rational design of multifunctional nanoplatform with target recognition, multiple imaging guidance/monitoring, and high-efficiency PTT