Delineating the Role of Osgin1 in Tissue Regeneration and Wound Healing in Xenopus laevis

Abstract

Embryonic development occurs through the cooperation of complex pathways that govern processes of cell proliferation and differentiation. Reactive oxygen species (ROS) play a crucial role in development because while some processes of oxidative stress are necessary for proper development, an overabundance of oxidative stress can harm the embryo. Through transcription of antioxidant genes, oxidative stress is regulated within the embryo. One such gene, Oxidative Stress Induced Growth Inhibitor 1 (Osgin1) has been shown to be upregulated in response to ROS. In order to understand the roles of this gene in embryonic development and tissue repair, whole mount in situ hybridization was performed to study spatiotemporal expression patterns. My data suggests a possible role for Osgin1 in neurodifferentiation and embryonic development.NeuroscienceBachelors of Science (BS