In this study, fucoidan, a polysaccharide derived from Sargassum wightii Greville ex J. Agardh, a brown seaweed, was used in the production of zinc oxide nanoparticles employing an eco-friendly,low cost-efficient process. Fucoidan served as a reducing, capping, and stabilizing agent. The Zinc oxide nanoparticles synthesized were subjected to analysis by Fourier transform infrared spectroscopy (FT-IR) and ultraviolet–visible spectroscopy (UV–VIS). The UV–Vis spectra exhibited a prominent absorption peak at approximately 370 nm. Furthermore, strong antibacterial activity was demonstrated by the phyto mediated-synthesized nanoparticles. To ascertain the potential of the produced nanoparticles to provide effective natural nano-medicine active and against microbial infection, the antibacterial activity was assessed, particularly against Gram harmful bacteria, Escherichia coli, and Gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis
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