Biosensors for Spaceflight Associated Neuro-ocular Syndrome (SANS)

Abstract

This project aims to develop miniaturized devices using nanotechnology and advanced materials like graphene and carbon nanotubes to continuously monitor physiological pressures, particularly intraocular pressure (IOP). Elevated IOP is a key marker in the diagnosis and treatment of Spaceflight Associated Neuro-ocular Syndrome, which is recognized as a health risk for NASA astronauts. Our approach involves designing a contact lens tonometer embedded with graphene-carbon nanotube nanocomposite films, which offer heightened sensitivity and real-time, non-invasive monitoring of IOP. Methods include the synthesis and fabrication of nanocomposite films, characterization of their mechanical and electrical properties, and integration into flexible contact lenses. Simulated ocular environments are going to be used to test the biosensors sensitivity and accuracy under dynamic pressure conditions. Preliminary results indicate that the graphene-carbon nanotube films provide reliable and highly sensitive IOP measurements. These findings suggest that the contact lens tonometer could offer a more effective way to monitor IOP, improving patient care for elevated IOP which can be seen in SANS or glaucoma. This research not only advances healthcare technology but also provides undergraduate students with valuable interdisciplinary research experience in biomedical engineering and materials science. The project contributes to future innovations in non-invasive medical devices, aiming to improve diagnostic accuracy and patient outcomes