Enzimski i lipidni markeri u proceni rizika za nastanak kardiovaskularnih bolesti kod žena u menopauzi

Abstract

Postmenopausal women are at an increased risk of cardiovascular disease (CVD), the leading cause of death worldwide, compared with younger women. Gamma-glutamyl transferase (GGT) and high-density lipoprotein cholesterol (HDL-c) are linked with oxidative stress, inflammation, insulin resistance, and CVD risk factors. However, there have been no studies that examined the relationship between GGT/HDL-c and CVD exclusively in women who are not of reproductive age. Therefore, we aimed to examine this potential relationship in a cohort of CVD- free postmenopausal women. A total of 150 disease-free postmenopausal women were consecutively included. CVD risk was defined according to high sensitivity C-reactive protein (hsCRP) concentration (hsCRP < 1 mg/L defines low risk and hsCRP ≥ 1 mg/L defines intermediate and high risk). The GGT/HDL-c was independently associated with intermediate and high CVD risk in postmenopausal women. As this enzyme/lipid index increased by 1 unit, the probability of intermediate and high CVD risk rose by 10.3% (OR = 1.103, p = 0.024). The GGT/HDL-c ratio was independently associated with higher CVD risk, as measured with hsCRP in postmenopausal women. This cost-effective, easily measured, and widely available index could be used in everyday clinical practice for estimating CVD risk in postmenopausal women.Žene u postmenopauzi su pod povećanim rizikom od kardiovaskularnih bolesti (KVB), vodećeg uzroka smrti širom sveta, u poređenju sa mlađim ženama. Gama-glutamil transferaza (GGT) i koncentracija holesterola u lipoproteinima visoke gustine (HDL-c) povezani su sa oksidativnim stresom, upalom, insulinskom rezistencijom i faktorima rizika za KVB. Međutim, ne postoje studije koje su ispitivale odnos između GGT/HDL-c i KVB isključivo kod žena koje nisu u reproduktivnom dobu. Stoga smo imali za cilj da ispitamo pomenuti potencijalni odnos u kohorti žena u postmenopauzi bez KVB. Ukupno je uključeno 150 zdravih žena u postmenopauzi. Rizik od KVB je definisan prema koncentraciji visokosenzitivnog C-reaktivnog proteina (hsCRP) (hsCRP < 1 mg/L definiše nizak rizik, a hsCRP ≥ 1 mg/L definiše srednji i visoki rizik). GGT/HDL-c je bio nezavisno povezan sa srednjim i visokim rizikom od KVB kod žena u postmenopauzi. S povećanjem ovog enzimskog/lipidnog indeksa za 1 jedinicu, verovatnoća srednjeg i visokog rizika od KVB porasla je za 10,3% (OR = 1,103, p = 0,024). Odnos GGT/HDL- c je nezavisno povezan sa većim rizikom od KVB, merenim pomoću hsCRP kod žena u postmenopauzi. Ovaj isplativ, lako merljiv i široko dostupan indeks mogao bi se koristiti u svakodnevnoj kliničkoj praksi za procenu rizika od KVB kod žena u postmenopauzi