MICROBIOTA-HOST EPIGENETIC AXIS IN OBSESSIVE COMPULSIVE DISORDER

Abstract

The underlying molecular mechanisms of OCD remain poorly understood. Emerging evidence suggests that microbiota composition, epigenetic regulation, and their effects on the dysregulation of endogenous signaling systems play crucial roles in the development and progression of this disorder. The overarching aim of this PhD research is thus to investigate the transcriptional regulation of genes belonging to selected endogenous systems in OCD and the possible role on these effects of microbiota dysregulation and of epigenetic mechanisms