Ischemia promotes hypertrophic nerve trunk formation and enteric neuron cell death in Hirschsprung's disease: Source data

Abstract

<table> <tbody> <tr> <td>Items</td> <td>Annotation</td> </tr> <tr> <td>ST-cluster_distrition.csv</td> <td>A table containing the number of ST-clusters across samples</td> </tr> <tr> <td>DEGs_C10_v_restCMusc.csv</td> <td>A table containing the result of DEG analysis for the comparison between ST cluster C10 and other muscular ST clusters (C8 and C9)</td> </tr> <tr> <td>DEGs_C13_v_C12.csv</td> <td>A table containing the result of DEG analysis for the comparison between ST cluster C13 (HNTs) and C12 (ganglia).</td> </tr> <tr> <td>DEGs_ST-cluster_total_marker.csv</td> <td>A table containing the markers for each ST cluster.</td> </tr> <tr> <td>DEGs_iMusc_ganglia_v_nMusc_ganglia.csv</td> <td>A table containing the result of DEG analysis for the comparison between ST iMusc_ganglia and nMusc_ganglia.</td> </tr> <tr> <td>DEGs_sc_all_markers.csv</td> <td>A table containing the markers of single-cell populations.</td> </tr> <tr> <td>DEGs_pseudotime_CLDN1.csv</td> <td>A table containing the results of gene differentially expressed during the differentiation from GREM1+ FLCs to CLDN1+ FLCs.</td> </tr> <tr> <td>Gene_set_score_for_C12_sub.csv</td> <td>A table containing the results of gene set score in the sub-population of ganglia (C12).</td> </tr> <tr> <td>STM_WES_FASTQ_meta_data.xlsx</td> <td>A table containing the ST-seq, scRNA-seq, and WES FASTQ file metadata.</td> </tr> <tr> <td>scRNA-seq_reference_raw.RDS</td> <td>A Seurat object containing the raw count and meta matrix of the single-cell reference </td> </tr> <tr> <td>ST-seq_raw_count.txt.gz</td> <td>A raw count matrix of ST-seq data</td> </tr> <tr> <td>ST-spots_meta_info.txt</td> <td>A table containing the metainformation of ST-seq data</td> </tr> <tr> <td>Object_of_bulk_RNA-seq.RDS</td> <td>A Seurat object used to reproduce the results of gene set scores in bulk RNA-seq.</td> </tr> <tr> <td>ST-spots_cell_abundance.txt</td> <td>A table containing the abundance of single-cell populations in each ST-spot.</td> </tr> <tr> <td>Cell_trajectory_of_FLCs.RDS</td> <td>A Seurat object used to reproduce the results of the cell trajectory of fibroblast-like cells.</td> </tr> <tr> <td>p_value_scRNA-seq_abundance.xlsx</td> <td>A table containing the p-value of cell abundance across groups for single-cell populations</td> </tr> <tr> <td>CIBERSORT_CPM_count_matrix.txt</td> <td>A table containing the CMP matrix of bulk RNA-seq data for CIBERSORT</td> </tr> <tr> <td>CIBERSORT_ST_raw_matrix.txt</td> <td>A table containing the raw count matrix of ST-seq data for CIBERSORT</td> </tr> <tr> <td>scRNA-seq_distribution.csv</td> <td>A table containing the distribution of single-cell populations across the sample</td> </tr> <tr> <td>DEGs_FLC_APOD_across_group.csv</td> <td>A table containing the DEGs in the comparison among APOD+ FLCs in different groups</td> </tr> <tr> <td>Gene_set_score_for_sc_Pericyte.csv</td> <td>A table containing the results of gene set score in the single-cell population of pericytes</td> </tr> <tr> <td>Gene_set_score_for_sc_Endo_score.csv</td> <td>A table containing the results of gene set score in the single-cell population of endothelial cells</td> </tr> <tr> <td>ENC_FLC_vessel_interaction.RDS</td> <td>A Cellchat object used to reproduce the results of cell-cell interaction among ENCs, glial cells, APOD+ FLCs, CLDN1+ FLCs, perictyes, and vascular endothelial cells.</td> </tr> <tr> <td>Metainfor_FASTQ1.xlsx</td> <td>Metainformation of FASTQ files</td> </tr> <tr> <td>Metainfor_FASTQ2.xlsx</td> <td>Metainformation of FASTQ files</td> </tr> </tbody> </table> <p> </p> <p> </p&gt