Rheumatoid arthritis (RA) is a chronic inflammation condition that affects over 17.6 million people. It primarily attacks joints making them stiff, swollen, painful and tender. This condition is usually linked to morbidity and mortality, and hence, knowing its risk factors is quite crucial. These are, but not limited to, diet, smoking, airborne, genetics, periodontitis, being a female, microbiota, and non-communicable diseases that respond to socioeconomic status. The inherent implication of how these factors synergize in enhancing the RA likelihood should not henceforth be overlooked while developing preventive strategies. Thus, this review serves to shed light on the correlation between these predisposing factors and the joint effect on development of this condition
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