World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
Abstract
Cypermethrin is a pyrethroid insecticide applied for pest control on
animals and the environment. Taurine is a putative antioxidant and
bioprotective amino acid. The purpose of the research was to evaluate
the impacts of taurine on oxidative stress indices in the sera and
brains of rats exposed to cypermethrin. Forty rats were assigned to
five groups of eight rats each. Distilled water was given to the first
group, while the second group received soya oil (2 ml/kg). Cypermethrin
(20 mg/kg) was administered to the third group. The
Taurine50+Cypermethrin group received taurine (50 mg/kg) and
cypermethrin, while the Taurine100+Cypermethrin group was administered
with taurine (100 mg/kg) and Cypermethrin. The treatments were given
once daily by oral gavage for 35 days. Sera were obtained from the
blood samples of the rats after the completion of the study for the
determination of the oxidative stress indices (malondialdehyde
concentration and the activities of antioxidant enzymes). Oxidative
stress indices were analysed in the brains. Taurine significantly
(P< 0.05) augmented the superoxide dismutase activity in the sera.
However, other oxidative stress indices were not ameliorated by taurine
in the sera and the brains. Cypermethrin (20 mg/kg) did not overtly
evoke oxidative stress in the sera and the brains of the rats in this
study, probably because it is a moderately toxic insecticide. This is
the first study that has investigated the effects of taurine on
cypermethrin toxicity. Further research is warranted to expound the
mechanisms of action of taurine and cypermethrin in biological systems
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