Fish disease control with the use of chemicals and antibiotics have been widely researched usefulness, perceived use of the above ingredients cause a lot of side issues especially when the use of such materials exceeding the threshold value. Based on the various studies that are now addressed to more effectively and efficiently with a minimum negative impact, both in prevention and in the effort to control or treatment. Based on the problems it is one of the ingredients selected as the material parasite control as well as sanitary materials and prevention of transmission of fish diseases are the leaves of the neem plant (Azadirachta indica A. Juss). Control pests by using neem as an insecticide plant have biological profit pest control. The long-term goal of this research is to gain Tilapia are free of parasites and is safe for consumption and fish farming environment safe from chemicals so that production can be increased and produce high-quality Tilapia fish consumption. The results were obtained kinds of types The types of parasites that attack Tilapia is Dactylogyrus sp, Gyrodactilus sp, Tricodina sp, Vorticella sp, Oodinium sp, Saprolegnia sp and after soaking the neem extract was found parasites Gyrodactilus at 25 ppm, the concentration of the most effective used is 20 ppm and the prevalence of Dactylogyrus sp, Gyrodactylus sp, Vorticella sp, Oodinium sp, and Saprolegnia sp is 0-40%, while Tricodina is 10-30% and the survival rate is between 84-100%
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