Evaluation of the protective effect of linalool compound in inhibiting renal damage caused by carbon tetrachloride in rats

Abstract

introduction: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney and liver. The aim of the current study is to determine the protective effects of linalool against CCl4-induced nephrotoxicity in rats. Methods: Eight-week-old male Wistar rats were divided into five groups (n=6): Normal control (a regular diet); Linalool control (25 mg/kg linalool daily); CCl4 group (1 ml/kg CCl4 dissolved in olive oil, intraperitoneally at 14th day); pretreatment group (25 mg/kg linalool daily+CCl4 14thday); Silymarin group (100 mg/kg of silymarin as the standard drug). On the fourteenth day, all animals were sacrificed, tissue and blood samples were collected to analysis. Results: Administration of CCl4 resulted in a marked increase in renal (blood urea nitrogen and creatinine) markers. Also, CCl4 resulted in pathological damages, a significant increase in the concentration of malondialdehyde and a significant decrease in the levels of serum total protein, serum albumin, and antioxidants. However, in pretreatment group, linalool significantly inhibited CCl4- induced kidney damages. Conclusion: These results demonstrate that linalool has protective effects in an in animal model of CCL4-induced kidney injury, proposing linalool as a potential therapeutic agent against chemical and drug induced nephrotoxicity