Therapeutic effect of Ananus comosus peel on 7, 12 dimethylbenz(a)anthracene induced breast cancer in female wistar albino rats

Abstract

Ananus comosus, has demonstrated a wide variety of biological activities which make it a good plant source for the treatment of many oxidative stress mediated diseases. The present study was aimed to evaluate therapeutic potential by assaying the activities of liver marker and lysosomal enzymes in 7, 12 dimethylbenz(?)anthracene induced mammary cancer bearing rats. Animals were divided into five groups of six numbers each. Group 1 served as control, group 2 induced mammary carcinogenesis, group 3 and 4 were treated with plant extract and tamoxifen and group 5 served as animals treated with plant extract alone. All the animals were sacrificed after 30 days treatment, serum and mammary tissue are used for the analysis of liver marker and lysosomal marker enzymes using standard protocols. The rats were induced with mammary cancer by DMBA showed altered the levels of liver markers and lysosomal marker enzymes in serum and mammary tissue. On the other hand, oral administrations of ethanolic extract of Ananus comosus peel and standard drug tamoxifen to mammary cancer bearing rats for 30 days, those levels were brought back to near normal. The histology of mammary tissues inevitably supports the biochemical alterations and this was attributed due to the interaction of Ananus comosus peel through the induction or inhibition of metabolism and also the modulating property in the marker and lysosomal enzymes