Optimization of Tween 80 and Span 60 on Cream Ethanol Extract the Leaves Matoa (Pometia Pinnata) as an Antioxidant

Abstract

Matoa is one of Papua’s endemic plants that have enormous potential for it is used in health as a nutrient, inhibits early aging process, and lowers the risk of some diseases. Matoa leaves extract (Pometia pinnata) contained compound class of flavonoids, alkaloids, tannins, saponins, terpenoids, and coumarins, so it can be utilized as one source of natural antioxidants that are good for the body. This study aims to determine the effect of Tween 80 and Span 60 on the physical quality of the optimum formula and test the antioxidant activity of ethanol leaves extract of matoa leaves. Determination of optimum formula using Simple Lattice Design (SLD) method. The results showed that the optimum composition was obtained on Tween 80: Span 60 of 50:50%. The cream with this optimum composition had a power of 3.35 cm; pH test 5.9; sticking power 58.60 sec. The optimum formula of ethanol extract of matoa leaves had a potent antioxidant activity potency with IC50 value of 40.6 ppm