Enantioselectivity in Modified Quinine Derivatives

Abstract

The main focus of this research was on derivatizing cinchonidine\u27s secondary hydroxyl group with various ester functional groups 2-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, and 4-hydroxyphenyl acetic acid in order for them to be used as chiral catalysts, which are important in the production of pharmaceuticals. Simple synthesis methods were shown to accurately create each derivatized catalyst compound for testing in asymmetric Micheal reactions to determine each compound\u27s feasibility as an effective chiral catalyst